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Estropipate

CAS No.: 7280-37-7

Chemical Name:: Estropipate

Synonyms: harmogen;sulestrex;Pipestrone;ESTROPIPATE;OESTROPIPATE;Estropipate (500 mg);Estropipate USP/EP/BP;Estropipate (1255500);Sulfate piperazine salt;piperazineestronesulfate

CBNumber:: CB8331281

Molecular Formula:: C22H32N2O5S

Molecular Weight:: 436.56

MOL File:: 7280-37-7.mol

Modify Date:: 2025/1/27 9:38:02

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Estropipate Properties

Melting point	245 °C
alpha	D25 +87.8° (c = 1 in 0.4% NaOH)
storage temp.	2-8°C
solubility	DMSO: ≥24mg/mL
pka	pKa 3.6/9.7(acetonitrile,80% v/v) (Uncertain)
form	powder
color	white to tan
optical activity	[α]/D 100 to 120°, c = 1 in DMSO
CAS DataBase Reference	7280-37-7(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS08

Signal word

Danger

Hazard statements

H302-H350

Precautionary statements

P201-P301+P312+P330-P308+P313

Hazard Codes

Risk Statements

45-22

Safety Statements

53-45

WGK Germany

RTECS

KG7785000

HS Code

2937230000

NFPA 704

	0
2		0

Estropipate price More Price(2)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	E2661	Estropipate ≥98% (HPLC), powder	7280-37-7	5MG	₹12849.28	2022-06-14	Buy
Sigma-Aldrich(India)	E2661	Estropipate ≥98% (HPLC), powder	7280-37-7	25MG	₹51884.23	2022-06-14	Buy

Product number	Packaging	Price	Buy
E2661	5MG	₹12849.28	Buy
E2661	25MG	₹51884.23	Buy

Estropipate Chemical Properties,Uses,Production

Uses

Estropipate is used in post-menopausal women for hormonal replacement therapy, with benefits to improved cognition and prevention of osteoporosis.

General Description

All the estrone 3-sulfate salts have the obvious pharmaceuticaladvantage of increased water solubility and better oralavailability. Acids convert the salts to the free 3-sulfate estersand cause some hydrolysis of the ester. This does not seem toaffect absorption adversely, but precipitation of the free sulfateesters in acidic pharmaceutical preparations should beavoided. The dibasic piperazine molecule acts as a buffer,giving it somewhat greater stability.

Biological Activity

Estrogen receptor agonist. Also inhibits organic anion transporting polypeptide 1B1 (OATP1B1) (IC 50 = 70 nM).

Safety Profile

Confirmed carcinogen. When heated to decomposition it emits toxic vapors of SOx and NOx.

Estropipate Preparation Products And Raw materials

Raw materials

Sodium hydroxide Ethyl acetate Benzene Chloroform Ethylbenzene

URINE

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Preparation Products

Estropipate Suppliers

Global( 121)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6257	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6739	58	Inquiry
SynZeal Research Pvt Ltd	+1 226-802-2078	Gujarat, India	6514	58	Inquiry
Pharma Affiliates	172-5066494	Haryana, India	6754	58	Inquiry
Capot Chemical Co.,Ltd.	+86-（0）57185586718 +86-13336195806	China	29730	60	Inquiry
Zhejiang ZETian Fine Chemicals Co. LTD	+8618957127338	China	2136	58	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49732	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29808	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	United States	32159	58	Inquiry
Hefei TNJ Chemical Industry Co.,Ltd.	+86-0551-65418671 +8618949823763	China	34563	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
SynZeal Research Pvt Ltd	58
Pharma Affiliates	58
Capot Chemical Co.,Ltd.	60
Zhejiang ZETian Fine Chemicals Co. LTD	58
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
TargetMol Chemicals Inc.	58
Hefei TNJ Chemical Industry Co.,Ltd.	58

Estropipate Spectrum

Estropipate(7280-37-7)MS

7280-37-7(Estropipate)Related Search:

Atropine sulfate Copper(II) sulfate Almestrone Ammonium sulfate Piperazine citrate

Magnesium sulfate Dimethyl sulfate Colistin sulfate Sodium sulfate FERROUS SULFATE

SULFATE STANDARD Estrone Potassium sulfate Neomycin sulfate Piperazine

SODIUM SULFATE Ferrous sulfate monohydrate sulfate

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3,5(10)-trien-17-one,3-(sulfooxy)-estra-compd.withpiperazine(1:1) Sulfate piperazine salt OESTROPIPATE PIPERAZINEESTRONESULPHATE PIPERAZINEOESTRONESULPHATE estrone sulfate piperazine salt Estra-1,3,5(10)-trien-17-one 3-sulphate piperazine (1:1) Estrone sulphate piperazine Estropipate (500 mg) 3-(Sulfooxy)-estra-1,3,5(10)-trien-17-one : piperazine (1:1) estrone,hydrogensulfate,compd.withpiperazine(1:1) harmogen piperazine,compd.with3-(sulfooxy)estra-1,3,5(10)-trien-17-one(1:1) piperazine,compd.withestronehydrogensulfate(1:1) piperazineestronesulfate sulestrex 1,3,5(10)-ESTRATRIEN-3-OL-17-ONE PIPERAZINE SULPHATE estra-1,3,5(10)-trien-17-one 3-sulphate, compound with piperazine (1:1) ESTRONE SULFATE PIPERAZINE ESTROPIPATE PIPERAZINE ESTRONE SULFATE;ESTRONE SULFATE PIPERAZINE SALT;HARMOGEN;OGEN Pipestrone Estropipate USP/EP/BP Estropipate (piperazine estrone sulfate) Estropipate (1255500) [(8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,14,15,16-octahydro-6H-cyclopenta[a]phenanthren-3-yl] hydrogen sulfate,piperazine Estropipate, 10 mM in DMSO 7280-37-7 C22H32N2O5S C18H22O5SC4H10N2 Steroids