DEGUELIN
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- ₹23436.13
- Product name: DEGUELIN
- CAS: 522-17-8
- MF: C23H22O6
- MW: 394.42
- EINECS:200-258-5
- MDL Number:MFCD01740600
- Synonyms:(7as-cis)-oxy- ;3h-bis(1)benzopyrano(3,4-b:6’,5’-e)pyran-7(7ah)-one,13,13a-dihydro-9,10-dimeth ;(7AS,13AS)-13,13A-DIHYDRO-9,10-DIMETHOXY-3,3-DIMETHYL-3H-BIS[1]BENZOPYRANO[3,4-B:6',5'-E]PYRAN-7(7AH)-ONE;(-)-DEGUELIN;DEGUELIN;(7aS,13aS)-13,13a-Dihydro-9,10-dimethoxy-3,3-dimethyl-(3H)-bis[1]benzopyrano[3.4-b.6'.5'-e]pyran-7(7aH)-one;(7aS)-3,3-Dimethyl-9,10-dimethoxy-7,7aα,13,13aα-tetrahydro-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7-one;3,3-Dimethyl-9,10-dimethoxy-7,7aα,13,13aα-tetrahydro-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7-one
1 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberD0817
- Product description(−)-Deguelin >98% (HPLC), powder
- Packaging5MG
- Price₹23436.13
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | D0817 | (−)-Deguelin >98% (HPLC), powder | 5MG | ₹23436.13 | 2022-06-14 | Buy |
Properties
Melting point :85-87 °C(lit.)
Boiling point :560.1±50.0 °C(Predicted)
alpha :D27 -97.2° (c = 0.2 in benzene)
Density :1?+-.0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >10 mg/mL
form :solid
color :white to yellow
optical activity :[α]/D -70 to -80°, c = 0.2 in methanol
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Boiling point :560.1±50.0 °C(Predicted)
alpha :D27 -97.2° (c = 0.2 in benzene)
Density :1?+-.0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: >10 mg/mL
form :solid
color :white to yellow
optical activity :[α]/D -70 to -80°, c = 0.2 in methanol
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Safety Information
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Description
Deguelin is a natural product that displays profound antiproliferative activity. Deguelin induces apoptosis, mediated through AKT/PKB signaling pathways in malignant and premaligant human bronchial epithelia (HBE) cells, with only minimal effects on normal HBE cells. Deguelin inhibits AKT by both PI 3-kinase dependent and PI 3-kinase independent pathways. Deguelin has displayed anti-tumor lymphangiogenesis and lymphatic metastasis by down-regulation of vascular endothelial cell growth factor-D in tumor models. Deguelin has also been shown to inhibit Cox-2 expression.More related product prices
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