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N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE

N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE Structure
  • ₹0
  • Product name: N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE
  • CAS: 261766-32-9
  • MF: C27H25ClN2O3
  • MW: 460.95
  • EINECS:
  • MDL Number:MFCD02683391
  • Synonyms:N-(2-PHENYLETHYL)-1-P-CHLOROBENZOYL-5-METHOXY-2-METHYLINDOLE-3-ACETAMIDE;N-(2-PHENYLETHYL)-1-(4-CHLOROBENZOYL)-5-METHOXY-2-METHYL-1H-INDOLE-3-ACETAMIDE;N-2PIA;N-(2-PHENYLETHYL)-INDOMETHACIN AMIDE;1-(4-Chlorobenzoyl)-5-Methoxy-2-Methyl-N-(2-phenylethyl)-1H-indole-3-acetaMide;LM 4108;Indomethacin N-Phenylethyl Impurity;1H-Indole-3-acetamide, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-N-(2-phenylethyl)-
Properties Safety Information Description
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

Boiling point :640.5±55.0 °C(Predicted)
Density :1.22±0.1 g/cm3(Predicted)
storage temp. :−20°C
solubility :≤80mg/ml in ethanol;10mg/ml in DMSO;14mg/ml in dimethyl formamide
pka :15.12±0.46(Predicted)
form :Pale yellow solid.

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

N-(2-phenylethyl)-indomethacin amide (N-2PIA) is one of several aromatic amides of indomethacin reported to be potent and selective reversible inhibitors of COX-2. N-2PIA inhibits human recombinant and ovine COX-2 with IC50 values of 0.06 and 0.125 μM, respectively. It is over 400 times less potent as an inhibitor of human recombinant and ovine COX-1. N-2PIA shows anti-inflammatory, antiangiogenic, and cancer chemopreventive activity in various experimental models.

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Suppliers and manufacturers

CLEARSYNTH LABS LTD.
Shenzhen Monkono Technology Co.,Ltd Cayman Chemical Company Shanghai EFE Biological Technology Co., Ltd. Shanghai YuZn Pharm. Technology Co.,Ltd. Beijing Lebo Biotechnology Co., Ltd. MedBioPharmaceutical Technology Inc SIGMA-RBI 3B Pharmachem (Wuhan) International Co.,Ltd. Toronto Research Chemicals