DUP-697
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- ₹0
- Product name: DUP-697
- CAS: 88149-94-4
- MF: C17H12BrFO2S2
- MW: 411.31
- EINECS:
- MDL Number:MFCD02684527
- Synonyms:DUP-697;5-BROMO-2-(4-FLUOROPHENYL)-3-(4-(METHYLSULFONYL)PHENYL)THIOPHENE;BFMeT;DuP-697 Assay Reagent;Thiophene, 5-bromo-2-(4-fluorophenyl)-3-[4-(methylsulfonyl)phenyl]-;DuP697,DuP 697
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Properties
storage temp. :2-8°C
solubility :DMF: 54 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 7 mg/ml
form :White to off-white solid.
color :White to off-white
solubility :DMF: 54 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 15 mg/ml; Ethanol: 7 mg/ml
form :White to off-white solid.
color :White to off-white
Safety Information
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Description
DuP-697 is a member of the diaryl heterocycle group of selective COX-2 inhibitors which includes MK-966 (rofecoxib), SC-58125, and celecoxib. DuP-697 is a potent and time-dependent inhibitor of COX-2. When tested on isolated recombinant enzymes, DuP-697 is at least 50 times more potent in the inhibition of COX-2 than COX-1. The IC50 values for human recombinant COX-2 are 80 and 40 nM at 5 and 10 minutes, respectively. The IC50 for the inhibition of human recombinant COX-1 after the same time intervals is 9 μM. DuP-697 also attenuates the COX-1 inhibitory activity of non-selective COX inhibitors such as indomethacin.More related product prices
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Suppliers and manufacturers
TargetMol Chemicals Inc.
Zhejiang J&C Biological Technology Co.,Limited
Hebei Miaoyin Technology Co.,Ltd
Aladdin Scientific
ShangHai ChuanQian Chemcial Technique Centre
Shanghai Aladdin Biochemical Technology Co.,Ltd.
RD International Technology Co., Limited
Chunchuang (Wuhan) Technology Co., Ltd
Suzhou Zhixin Biotechnology Co., Ltd.
Nantong QuanYi Biotechnology Co., Ltd