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Sulindac sulfide

Sulindac sulfide Structure
  • ₹6780 - ₹36970
  • Product name: Sulindac sulfide
  • CAS: 32004-67-4
  • MF: C20H17FO2S
  • MW: 340.41
  • EINECS:250-892-2
  • MDL Number:MFCD00869764
  • Synonyms:5-FLUORO-2-METHYL-1-(4-METHYLTHIOBENZYLIDENE)INDEN-3-YLACETIC ACID;(Z)-5-FLUORO-2-METHYL-1-[P-(METHYLTHIO)BENZYLIDENE]INDENE-3-ACETIC ACID;SULINDAC SULPHIDE;SULINDAC SULFIDE;5-fluoro-2-methyl-1-[[4-(methylthio)phenyl]methylene]-1H-indene-3-acetic acid ;5-FLUORO-2-METHYL-1-(4-METHYLTHIOBENZYLIDENE)INDEN-3-YLACETIC ACID [SULINDAC SULFIDE ];5-F;1H-Indene-3-acetic acid, 5-fluoro-2-methyl-1-((4-(methylthio)phenyl)methylene)-
4 prices
Selected condition:

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerTCI Chemicals (India)
  • Product numberS0906
  • Product descriptionSulindac Sulfide
  • Packaging25MG
  • Price₹10900
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberS3131
  • Product descriptionSulindac sulfide ≥98% (HPLC), solid
  • Packaging5MG
  • Price₹6780
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number574102
  • Product descriptionSulindac Sulfide - CAS 32004-67-4 - Calbiochem A cell-permeable, active metabolite of Sulindac.
  • Packaging5MG
  • Price₹9490
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberS3131
  • Product descriptionSulindac sulfide ≥98% (HPLC), solid
  • Packaging25MG
  • Price₹36970
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) S0906 Sulindac Sulfide 25MG ₹10900 2022-05-26 Buy
Sigma-Aldrich(India) S3131 Sulindac sulfide ≥98% (HPLC), solid 5MG ₹6780 2022-06-14 Buy
Sigma-Aldrich(India) 574102 Sulindac Sulfide - CAS 32004-67-4 - Calbiochem A cell-permeable, active metabolite of Sulindac. 5MG ₹9490 2022-06-14 Buy
Sigma-Aldrich(India) S3131 Sulindac sulfide ≥98% (HPLC), solid 25MG ₹36970 2022-06-14 Buy

Properties

Melting point :189-191°C
Boiling point :526.3±50.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
RTECS :NK8236000
storage temp. :+15C to +30C
solubility :DMSO: >22 mg/mL
form :solid
pka :4.26±0.10(Predicted)
color :yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference :32004-67-4(CAS DataBase Reference)

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
Precautionary statements:
P201 Obtain special instructions before use.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P308+P313 IF exposed or concerned: Get medical advice/attention.

Description

It is also shown to inhibit growth and induce apoptosis in human prostate cancer cells through a COX-1 and COX-2 independent mechanism. Sulindac sulfide is an analgesic that has antiproliferative and apoptotic effects. It inhibits the expression and activity of cyclooxygenase-2 in human colon cancer cells, and reduces tumor burden in adenomatous polyposis patients. Human endothelial cells, HMEC-1 were treated with Sulindac sulfide and the effect on cell survival was studies by MTT assay.

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