SC-560
- ₹7300 - ₹24486.15
- Product name: SC-560
- CAS: 188817-13-2
- MF: C17H12ClF3N2O
- MW: 352.74
- EINECS:
- MDL Number:MFCD02179214
- Synonyms:SC-560;5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-(TRIFLUOROMETHYL)-1H-PYRAZOLE;5-(4-CHLOROPHENYL)-1-(4-METHOXYPHENYL)-3-TRIFLUOROMETHYLPYRAZOLE;SC-560 Assay Reagent;1H-Pyrazole, 5-(4-chlorophenyl)-1-(4-Methoxyphenyl)-3-(trifluoroMethyl)-;5-(4-Chlorophenyl)-3-(trifluoromethyl)-1-(4-methoxyphenyl)-1H-pyrazole;5-(4-Chlorophenyl);SC-560 - CAS 188817-13-2 - Calbiochem
3 prices
Selected condition:
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- 100MG
- ManufacturerTCI Chemicals (India)
- Product numberC3572
- Product descriptionSC-560
- Packaging25MG
- Price₹7300
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberC3572
- Product descriptionSC-560
- Packaging100MG
- Price₹19800
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberS2064
- Product descriptionSC-560 ≥98% (HPLC)
- Packaging5MG
- Price₹24486.15
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
TCI Chemicals (India) | C3572 | SC-560 | 25MG | ₹7300 | 2022-05-26 | Buy |
TCI Chemicals (India) | C3572 | SC-560 | 100MG | ₹19800 | 2022-05-26 | Buy |
Sigma-Aldrich(India) | S2064 | SC-560 ≥98% (HPLC) | 5MG | ₹24486.15 | 2022-06-14 | Buy |
Properties
Melting point :63 °C
Boiling point :440.6±45.0 °C(Predicted)
Density :1.33
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
form :Off-white solid
pka :-3?+-.0.10(Predicted)
color :White to Light yellow to Light orange
Boiling point :440.6±45.0 °C(Predicted)
Density :1.33
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
form :Off-white solid
pka :-3?+-.0.10(Predicted)
color :White to Light yellow to Light orange
Safety Information
Symbol(GHS): | |||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Signal word: | Warning | ||||||||||||||||||||||||||||
Hazard statements: |
|
||||||||||||||||||||||||||||
Precautionary statements: |
|
Description
SC-560 is a member of the diaryl heterocycle class of cyclooxygenase (COX) inhibitors which includes celecoxib (Celebrex?) and rofecoxib (Vioxx?). However, unlike these selective COX-2 inhibitors, SC-560 is a selective inhibitor of COX-1. Using human recombinant enzymes, the IC50 value for SC-560 with respect to COX-1 is 9 nM, while the corresponding IC50 value for COX-2 is 6.3 μM. Thus, SC-560 shows 700-fold selectivity for the COX-1 enzyme. SC-560 is orally active in the rat, where 10 mg/kg completely abolishes the ionophore-induced production of thromboxane B2 in whole blood. However, SC-560 is ineffective in the treatment of inflammation in models such as the LPS-induced rat air-pouch model, in which the COX-2 generated prostaglandins play a significant role in the inflammatory process. In whole cells, however, SC-560 appears to act as a non-selective COX inhibitor. The mechanism of the selective versus non-selective effects of SC-560 in a cell-free environment compared whole cells has not been elucidated.More related product prices
(S)-(+)-Ibuprofen Piroxicam Indometacin NS-398 Meloxicam 170569-86-5 (R)-(-)-IBUPROFEN Phenidone Ibuprofen SULINDAC SULFIDE MECLOFENAMATE SODIUM 218136-59-5 SC-1 4-ThiazolecarboxaMide, N-(6-benzoyl-1H-benziMidazol-2-yl)-2-(1-thieno[3,2-d]pyriMidin-4-yl-4-piperidinyl)- 261766-32-9Related product price
- (S)-(+)-Ibuprofen
₹3700-11214.7 - Piroxicam
₹6051.18-40225.7 - Indometacin
₹3399.05-64084