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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Cytoskeletal Signaling >PAK inhibitors >IPA-3

IPA-3

IPA-3 Structure
  • ₹8310 - ₹42661.33
  • Product name: IPA-3
  • CAS: 42521-82-4
  • MF: C20H14O2S2
  • MW: 350.45
  • EINECS:
  • MDL Number:MFCD00388917
  • Synonyms:1,1'-Dithiodi-2-naphthtol;IPA 3;p21-Activated Kinase Inhibitor III, IPA-3;Bis(2-hydroxy-1-naphthyl) disulfide;2-Naphthalenol, 1,1'-dithiobis-;1,1′-Disulfanediyldinaphthalen-2-ol;1,1'-Disulfanediylbis(naphthalen-2-ol);IPA 3;IPA3
Price4 Properties Safety Information Description
4 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product number506106
  • Product descriptionp21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem The p21-Activated Kinase Inhibitor III, IPA-3, also referenced under CAS 42521-82-4, controls the biological activity of p21-Activated Kinase. This sm
  • Packaging5MG
  • Price₹8310
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberI2285
  • Product descriptionIPA-3 ≥95% (HPLC), powder
  • Packaging5MG
  • Price₹10695.1
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number506106
  • Product descriptionp21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem The p21-Activated Kinase Inhibitor III, IPA-3, also referenced under CAS 42521-82-4, controls the biological activity of p21-Activated Kinase. This sm
  • Packaging25MG
  • Price₹27450.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberI2285
  • Product descriptionIPA-3 ≥95% (HPLC), powder
  • Packaging25MG
  • Price₹42661.33
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 506106 p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem The p21-Activated Kinase Inhibitor III, IPA-3, also referenced under CAS 42521-82-4, controls the biological activity of p21-Activated Kinase. This sm 5MG ₹8310 2022-06-14 Buy
Sigma-Aldrich(India) I2285 IPA-3 ≥95% (HPLC), powder 5MG ₹10695.1 2022-06-14 Buy
Sigma-Aldrich(India) 506106 p21-Activated Kinase Inhibitor III, IPA-3 - CAS 42521-82-4 - Calbiochem The p21-Activated Kinase Inhibitor III, IPA-3, also referenced under CAS 42521-82-4, controls the biological activity of p21-Activated Kinase. This sm 25MG ₹27450.01 2022-06-14 Buy
Sigma-Aldrich(India) I2285 IPA-3 ≥95% (HPLC), powder 25MG ₹42661.33 2022-06-14 Buy

Properties

Melting point :172℃
Boiling point :543.7±35.0 °C(Predicted)
Density :1.46±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: >20mg/mL
pka :7.52±0.50(Predicted)
form :Yellow solid
color :off-white to yellow
Water Solubility :Soluble in DMSO or ethanol. Insoluble in water.
Sensitive :Light Sensitive
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
CAS DataBase Reference :42521-82-4

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger GHS hazard pictograms P280, P305+P351+P338, P310
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P501 Dispose of contents/container to..…

Description

p21-activated kinase 1 (PAK1) is a member of a family non-receptor serine/threonine kinases that are vital to normal cell function. Binding of various upstream partners to PAK1 results in release of an autoinhibitory domain that blocks activity of the kinase domain. PAK1 expression and activity is upregulated in several human cancers and is a potential therapeutic target for cancer intervention. IPA-3 is a cell-permeable allosteric inhibitor of PAK1 that is non-competitive with respect to ATP binding (IC50 = 2.5 μM). It does not, however, inhibit the activity of PAK1 that has been pre-activated with Cdc42. IPA-3 binds covalently to the PAK1 regulatory domain (apparent Kd = 1.9 uM) and prevents binding to the upstream activator Cdc42.

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