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MAFP

MAFP Structure
  • ₹21745 - ₹24994.93
  • Product name: MAFP
  • CAS: 188404-10-6
  • MF: C21H36FO2P
  • MW: 370.48
  • EINECS:201-185-2
  • MDL Number:MFCD03095722
  • Synonyms:5Z,8Z,11Z,14Z-EICOSATETRAENYL-PHOSPHONOFLUORIDIC ACID, METHYL ESTER;(5Z,8Z,11Z,14Z)-5,8,11,14-EICOSATETRAENYL-METHYL ESTER PHOSPHONOFLUORIDIC ACID;MAFP;MAPF;METHYL-5Z,8Z,11Z,14Z-EICOSATETRAENYL ESTER PHOSPHONOFLUORIDIC ACID METHYL ACETATE;METHYL ARACHIDONYL FLUOROPHOSPHONATE;METHYLPHOSPHONOFLUORIDIC ACID 5,8,11,14-EICOSATETRAENYL ESTER;(5Z,8Z,11Z,14Z)-5,8,11,14-Eicosatetraenylmethylester
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • ALFA India
  • Sigma-Aldrich(India)

Package

  • 5mg
  • ManufacturerALFA India
  • Product numberALF-J67139-LB0
  • Product descriptionMethyl arachidonyl fluorophosphonate, 98%
  • Packaging5mg
  • Price₹21745
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberM2939
  • Product descriptionMethyl arachidonyl fluorophosphonate ≥98%, methyl acetate solution (10 mg/mL)
  • Packaging5MG
  • Price₹24994.93
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ALFA India ALF-J67139-LB0 Methyl arachidonyl fluorophosphonate, 98% 5mg ₹21745 2022-05-26 Buy
Sigma-Aldrich(India) M2939 Methyl arachidonyl fluorophosphonate ≥98%, methyl acetate solution (10 mg/mL) 5MG ₹24994.93 2022-06-14 Buy

Properties

Boiling point :455.3±34.0 °C(Predicted)
Density :0.960±0.06 g/cm3(Predicted)
RTECS :TA8108000
Flash point :-16 °C
storage temp. :-70°C
solubility :DMF: 3 mg/ml; DMSO: 3 mg/ml; Ethanol: 3.5 mg/ml; Ethanol:PBS (pH 7.2) 1:1: .5 mg/ml; PBS (7.2): <1 mg/ml (colloidal suspension
form :methyl acetate solution
color :Light yellow to yellow
Sensitive :Air Sensitive

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger GHS hazard pictograms P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H336 May cause drowsiness or dizziness Specific target organ toxicity,single exposure; Narcotic effects Category 3 Warning P261, P271, P304+P340, P312,P403+P233, P405, P501
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Methyl arachidonyl fluorophosphonate (MAFP) is a selective, active-site directed, irreversible inhibitor of cPLA2 and iPLA2. It inhibits A23187-induced arachidonic acid release from human platelets with an IC50 value of 0.6 μM. The IC50 value for inhibition of iPLA2 from P388D1 cells is 0.5 μM. MAFP is a potent inhibitor of fatty acid amide hydrolase, exhibiting an IC50 value of 2.5 nM. MAFP also binds to the CB1 receptor in rat brain membrane preparations. The IC50 values for MAFP and arachidonyl ethanolamide in this assay are 20 and 40 nM, respectively.

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Suppliers and manufacturers

Alfa Aesar
TargetMol Chemicals Inc.
Aladdin Scientific RD International Technology Co., Limited SHANGHAI ZZBIO CO., LTD. Beijing Solarbio Science & Tecnology Co., Ltd. TargetMol Chemicals Inc. Cayman Chemical Company Shanghai EFE Biological Technology Co., Ltd. Tianjin Kailiqi Biotechnology Co., Ltd.