SP2509
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- ₹21209.99
- Product name: SP2509
- CAS: 1423715-09-6
- MF: C19H20ClN3O5S
- MW: 437.9
- EINECS:-0
- MDL Number:MFCD28348370
- Synonyms:(E)-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide;HCI-2509;(E)-N'-(1-(5-chloro-2-hydroxyphenyl)ethylidene)-3-(morpholinosulfonyl)benzohydrazide SP2509;SP2509;3-(4-Morpholinylsulfonyl)benzoic acid (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide;SP-2509;HCI-2509;SP 2509;SP-2509;CS-1755
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Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number5.09703
- Product descriptionLSD1 Inhibitor VII, SP-2509 - CAS 1423715-09-6 - Calbiochem A cell-permeable, potent, selective, reversible inhibitor of Lysine-Specific Demethylase 1 (LSD1; IC?? = 13 nM; Ki = 31 nM).
- Packaging10MG
- Price₹21209.99
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 5.09703 | LSD1 Inhibitor VII, SP-2509 - CAS 1423715-09-6 - Calbiochem A cell-permeable, potent, selective, reversible inhibitor of Lysine-Specific Demethylase 1 (LSD1; IC?? = 13 nM; Ki = 31 nM). | 10MG | ₹21209.99 | 2022-06-14 | Buy |
Properties
Density :1.44±0.1 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :Off-white solid
pka :7.96±0.43(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
storage temp. :+2C to +8C
solubility :Soluble in DMSO (up to at least 25 mg/ml)
form :Off-white solid
pka :7.96±0.43(Predicted)
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Safety Information
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Description
Lysine-specific demethylase 1 (LSD1) is a protein lysine demethylase that specifically demethylates histone H3 lysine 4 (H3K4), resulting in transcriptional repression. SP2509 is a reversible inhibitor of LSD1 (IC50 = 13 nM). It has no effect on monoamine oxidases A and B. SP2509 attenuates the binding of LSD1 to CoREST, allowing increased methylation of H3K4 and driving increased expression of p21, p27, and CCAAT/enhancer binding protein α in cultured acute myeloid leukemia (AML) cells. It improves survival of mice with AML xenografts when given (25 mg/kg biweekly via intraperitoneal injection) for three weeks. Co-treatment of SP2509 with the pan-HDAC inhibitor panobinostat synergistically kills AML cells in vitro and improves survival of mice engrafted with AML cells.More related product prices
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