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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Cytoskeletal Signaling >HSP e.g. HSP90 inhibitors >BIIB-021

BIIB-021

BIIB-021 Structure
  • ₹39906 - ₹58509
  • Product name: BIIB-021
  • CAS: 848695-25-0
  • MF: C14H15ClN6O
  • MW: 318.76
  • EINECS:812-781-2
  • MDL Number:MFCD15528939
  • Synonyms:CNF2024;9-[2-(2,2-diMethyl-propylaMino)ethyl]-8-(2-iodo-5-Methoxy-phenylsulfanyl)-9H-purin-6-ylaMine;CNF-2024EC102;9H-Purin-2-aMine, 6-chloro-9-[(4-Methoxy-3,5-diMethyl-2-pyridinyl)Methyl]-;6-chloro-9-((4-Methoxy-3,5-diMethylpyridin-2-yl)Methyl)-9H-purin-2-aMine;BIIB-021;BIIB021/CNF2024;6-Chloro-9-[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]-9H-purin-2-amine
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • ottokemi

Package

  • 5mg
  • 10mg
  • Manufacturerottokemi
  • Product number B 8637
  • Product descriptionBIIB 021, ≥98%
  • Packaging5mg
  • Price₹39906
  • Updated2022-05-26
  • Buy
  • Manufacturerottokemi
  • Product number B 8637
  • Product descriptionBIIB 021, ≥98%
  • Packaging10mg
  • Price₹58509
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
ottokemi B 8637 BIIB 021, ≥98% 5mg ₹39906 2022-05-26 Buy
ottokemi B 8637 BIIB 021, ≥98% 10mg ₹58509 2022-05-26 Buy

Properties

Melting point :192-193℃
Boiling point :588.5±60.0 °C(Predicted)
Density :1.50
storage temp. :-20°C
solubility :Soluble in DMSO (>25 mg/ml)
form :solid
pka :6.07±0.40(Predicted)
color :White
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20°C for up to 3 montha.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

BIIB021 is a potent, orally-available inhibitor of Hsp90 (Ki = 1.7 nM) that induces the degradation of oncoproteins, including HER2 (EC50 = 38 nM), while up-regulating the expression of Hsp70 and Hsp27. It is cytotoxic to cancer cells and, when administered orally to mice, inhibits growth of xenograft tumors. BIIB021 suppresses growth in various lymphoma cells but not in normal lymphocytes and induces apoptosis in a myelodysplastic syndrome cell line.

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Suppliers and manufacturers

TargetMol Chemicals Inc.
BIIB021
₹48.00 /5mg
BIIB021 CAS:848695-25-0
A.J Chemicals CLEARSYNTH LABS LTD. Otto Chemie Pvt. Ltd.
ATK CHEMICAL COMPANY LIMITED
CONIER CHEM AND PHARMA LIMITED
Dideu Industries Group Limited
Zhejiang J&C Biological Technology Co.,Limited
InvivoChem
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