Etoposide
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- ₹7605 - ₹1797560.2
- Product name: Etoposide
- CAS: 33419-42-0
- MF: C29H32O13
- MW: 588.56
- EINECS:251-509-1
- MDL Number:MFCD00869325
- Synonyms:(-)-Etoposide, (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside;EtoposideETOPOSIDE
CAS:33419-42-0
MES-012;BMY-40481, Etoposide 4'-Dihydrogenphosphate, VP-16-213;Etoposide , 98.0%(LC);Etoposide for system suitability;GAL4 [(1-147) + VP16 (411-490)] from Saccharomyces cerevisiae human herpesvirus 2;Etoposide, >=98%;(5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one
13 prices
Selected condition：
Brand
- Sigma-Aldrich
- TCI Chemicals (India)
- Sigma-Aldrich(India)
- ottokemi
Package
- 1gm
- 500μG
- 250MG
- 10μG
- 25MG
- 100MG
- 1G
- ManufacturerSigma-Aldrich
- Product number341205
- Product descriptionEtoposide - CAS 33419-42-0 - Calbiochem A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC?? = 59.2 μM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung
- Packaging25MG
- Price₹8739.99
- Updated2022-06-14
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberE0675
- Product descriptionEtoposide
- Packaging100MG
- Price₹11500
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberE0675
- Product descriptionEtoposide
- Packaging1G
- Price₹23400
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number341205
- Product descriptionEtoposide - CAS 33419-42-0 - Calbiochem A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC?? = 59.2 μM) has major activity against a number of tumor
- Packaging25MG
- Price₹8739.99
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberE1383
- Product descriptionEtoposide synthetic, 95.0-105.0%, powder
- Packaging25MG
- Price₹9883.23
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberE1383
- Product descriptionEtoposide synthetic, 95.0-105.0%, powder
- Packaging100MG
- Price₹27863.55
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSRP2017
- Product descriptionGAL4 [(1-147) + VP16 (411-490)] from Saccharomyces cerevisiae human herpesvirus 2 recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
- Packaging10μG
- Price₹40796.8
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberE1383
- Product descriptionEtoposide synthetic, 95.0-105.0%, powder
- Packaging250MG
- Price₹54265.73
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSRP2017
- Product descriptionGAL4 [(1-147) + VP16 (411-490)] from Saccharomyces cerevisiae human herpesvirus 2 recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
- Packaging500μG
- Price₹1797560.2
- Updated2022-06-14
- Buy
- Manufacturerottokemi
- Product number E 7192
- Product descriptionEtoposide synthetic, 98.0-105.0%, powder 98%
- Packaging25mg
- Price₹7605
- Updated2022-05-26
- Buy
- Manufacturerottokemi
- Product number E 7192
- Product descriptionEtoposide synthetic, 98.0-105.0%, powder 98%
- Packaging100mg
- Price₹9594
- Updated2022-05-26
- Buy
- Manufacturerottokemi
- Product number E 7192
- Product descriptionEtoposide synthetic, 98.0-105.0%, powder 98%
- Packaging250mg
- Price₹12906
- Updated2022-05-26
- Buy
- Manufacturerottokemi
- Product number E 7192
- Product descriptionEtoposide synthetic, 98.0-105.0%, powder 98%
- Packaging1gm
- Price₹19494
- Updated2022-05-26
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich | 341205 | Etoposide - CAS 33419-42-0 - Calbiochem A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC?? = 59.2 μM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung | 25MG | ₹8739.99 | 2022-06-14 | Buy |
| TCI Chemicals (India) | E0675 | Etoposide | 100MG | ₹11500 | 2022-05-26 | Buy |
| TCI Chemicals (India) | E0675 | Etoposide | 1G | ₹23400 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | 341205 | Etoposide - CAS 33419-42-0 - Calbiochem A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC?? = 59.2 μM) has major activity against a number of tumor | 25MG | ₹8739.99 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E1383 | Etoposide synthetic, 95.0-105.0%, powder | 25MG | ₹9883.23 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E1383 | Etoposide synthetic, 95.0-105.0%, powder | 100MG | ₹27863.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SRP2017 | GAL4 [(1-147) + VP16 (411-490)] from Saccharomyces cerevisiae human herpesvirus 2 recombinant, expressed in E. coli, ≥80% (SDS-PAGE) | 10μG | ₹40796.8 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | E1383 | Etoposide synthetic, 95.0-105.0%, powder | 250MG | ₹54265.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SRP2017 | GAL4 [(1-147) + VP16 (411-490)] from Saccharomyces cerevisiae human herpesvirus 2 recombinant, expressed in E. coli, ≥80% (SDS-PAGE) | 500μG | ₹1797560.2 | 2022-06-14 | Buy |
| ottokemi | E 7192 | Etoposide synthetic, 98.0-105.0%, powder 98% | 25mg | ₹7605 | 2022-05-26 | Buy |
| ottokemi | E 7192 | Etoposide synthetic, 98.0-105.0%, powder 98% | 100mg | ₹9594 | 2022-05-26 | Buy |
| ottokemi | E 7192 | Etoposide synthetic, 98.0-105.0%, powder 98% | 250mg | ₹12906 | 2022-05-26 | Buy |
| ottokemi | E 7192 | Etoposide synthetic, 98.0-105.0%, powder 98% | 1gm | ₹19494 | 2022-05-26 | Buy |
Properties
Melting point :236-251 °C (lit.)
Boiling point :563.9°C (rough estimate)
alpha :D20 -110.5° (c = 0.6 in chloroform)
Density :1.2966 (rough estimate)
refractive index :-110.5 ° (C=0.6, CHCl3)
storage temp. :2-8°C
solubility :DMSO: 30 mg/mL
form :powder
pka :9.8(at 25℃)
color :white
Water Solubility :Insoluble in water.
Merck :14,3886
BCS Class :4
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
IARC :1 (Vol. 76, 100A) 2012, 1 (Vol. 76, 100A) 2012
EPA Substance Registry System :Etoposide (33419-42-0)
Boiling point :563.9°C (rough estimate)
alpha :D20 -110.5° (c = 0.6 in chloroform)
Density :1.2966 (rough estimate)
refractive index :-110.5 ° (C=0.6, CHCl3)
storage temp. :2-8°C
solubility :DMSO: 30 mg/mL
form :powder
pka :9.8(at 25℃)
color :white
Water Solubility :Insoluble in water.
Merck :14,3886
BCS Class :4
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
IARC :1 (Vol. 76, 100A) 2012, 1 (Vol. 76, 100A) 2012
EPA Substance Registry System :Etoposide (33419-42-0)
Safety Information
| Symbol(GHS): |
 
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| Signal word: | Danger | ||||||||||||||||||||||||||||
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Description
Etoposide is a plant alkaloid which acts as an inhibitor of topoisomerase II (IC50 = 60.3 μM). Notably, this compound can have much greater potencies when evaluated in cell-based cytotoxicity assays (e.g., IC50 = 5.14 nM for MCF-7 cells). Etoposide inhibits DNA synthesis by forming a ternary complex with DNA and topoisomerase II, inducing breaks in double stranded DNA. Accumulated breaks in DNA prevent entry into mitosis and lead to cell death. Recent bioassay data suggest that etoposide can also inhibit nuclear receptor coactivator 3 (IC50 = 2.48 μM), a steroid receptor coactivator with histone acetyltransferase activity. Interestingly, histone deacetylase inhibitors can sensitize multidrug-resistant cancer cells to etoposide.Related product price
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