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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Natural sources of antineoplastic >Etoposide

Etoposide

₹7605 - ₹1797560.2
Product name: Etoposide
CAS: 33419-42-0
MF: C29H32O13
MW: 588.56
EINECS:251-509-1
MDL Number:MFCD00869325
Synonyms:(-)-Etoposide, (5S,5aR,8aR,9R)-9-(4-hydroxy-3,5-dimethoxyphenyl)-8-oxo-5,5a,6,8,8a,9-hexahydrofuro[3',4':6,7]naphtho[2,3-d][1,3]dioxol-5-yl 4,6-O-[(1R)-ethylidene]-beta-D-glucopyranoside;EtoposideETOPOSIDE
CAS:33419-42-0
MES-012;BMY-40481, Etoposide 4'-Dihydrogenphosphate, VP-16-213;Etoposide , 98.0%(LC);Etoposide for system suitability;GAL4 [(1-147) + VP16 (411-490)] from Saccharomyces cerevisiae human herpesvirus 2;Etoposide, >=98%;(5R,5aR,8aR,9S)-9-[[4,6-O-(1R)-Ethylidene-β-D-glucopyranosyl]oxy]-5,8,8a,9-tetrahydro-5-(4-hydroxy-3,5-dimethoxyphenyl)furo[3',4':6,7]naphtho[2,3-d]-1,3-dioxol-6(5aH)-one

Price13 Properties Safety Information Description

13 prices

Selected condition：

Brand

Sigma-Aldrich
Sigma-Aldrich(India)
TCI Chemicals (India)
ottokemi

Package

10μG
1G
1gm
500μG
25MG
100MG
250MG

ManufacturerSigma-Aldrich
Product number341205
Product descriptionEtoposide - CAS 33419-42-0 - Calbiochem A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC?? = 59.2 μM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung
Packaging25MG
Price₹8739.99
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product number341205
Product descriptionEtoposide - CAS 33419-42-0 - Calbiochem A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC?? = 59.2 μM) has major activity against a number of tumor
Packaging25MG
Price₹8739.99
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product numberE1383
Product descriptionEtoposide synthetic, 95.0-105.0%, powder
Packaging25MG
Price₹9883.23
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product numberE1383
Product descriptionEtoposide synthetic, 95.0-105.0%, powder
Packaging100MG
Price₹27863.55
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product numberE1383
Product descriptionEtoposide synthetic, 95.0-105.0%, powder
Packaging250MG
Price₹54265.73
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product numberSRP2017
Product descriptionGAL4 [(1-147) + VP16 (411-490)] from Saccharomyces cerevisiae human herpesvirus 2 recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Packaging500μG
Price₹1797560.2
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product numberSRP2017
Product descriptionGAL4 [(1-147) + VP16 (411-490)] from Saccharomyces cerevisiae human herpesvirus 2 recombinant, expressed in E. coli, ≥80% (SDS-PAGE)
Packaging10μG
Price₹40796.8
Updated2022-06-14
Buy

ManufacturerTCI Chemicals (India)
Product numberE0675
Product descriptionEtoposide
Packaging1G
Price₹23400
Updated2022-05-26
Buy

ManufacturerTCI Chemicals (India)
Product numberE0675
Product descriptionEtoposide
Packaging100MG
Price₹11500
Updated2022-05-26
Buy

Manufacturerottokemi
Product number E 7192
Product descriptionEtoposide synthetic, 98.0-105.0%, powder 98%
Packaging1gm
Price₹19494
Updated2022-05-26
Buy

Manufacturerottokemi
Product number E 7192
Product descriptionEtoposide synthetic, 98.0-105.0%, powder 98%
Packaging250mg
Price₹12906
Updated2022-05-26
Buy

Manufacturerottokemi
Product number E 7192
Product descriptionEtoposide synthetic, 98.0-105.0%, powder 98%
Packaging100mg
Price₹9594
Updated2022-05-26
Buy

Manufacturerottokemi
Product number E 7192
Product descriptionEtoposide synthetic, 98.0-105.0%, powder 98%
Packaging25mg
Price₹7605
Updated2022-05-26
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Sigma-Aldrich	341205	Etoposide - CAS 33419-42-0 - Calbiochem A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC?? = 59.2 μM) has major activity against a number of tumors, including germ cell neoplasms, small cell lung	25MG	₹8739.99	2022-06-14	Buy
Sigma-Aldrich(India)	341205	Etoposide - CAS 33419-42-0 - Calbiochem A cell-permeable derivative of podophyllotoxin that acts as a topoisomerase II inhibitor (IC?? = 59.2 μM) has major activity against a number of tumor	25MG	₹8739.99	2022-06-14	Buy
Sigma-Aldrich(India)	E1383	Etoposide synthetic, 95.0-105.0%, powder	25MG	₹9883.23	2022-06-14	Buy
Sigma-Aldrich(India)	E1383	Etoposide synthetic, 95.0-105.0%, powder	100MG	₹27863.55	2022-06-14	Buy
Sigma-Aldrich(India)	E1383	Etoposide synthetic, 95.0-105.0%, powder	250MG	₹54265.73	2022-06-14	Buy
Sigma-Aldrich(India)	SRP2017	GAL4 [(1-147) + VP16 (411-490)] from Saccharomyces cerevisiae human herpesvirus 2 recombinant, expressed in E. coli, ≥80% (SDS-PAGE)	500μG	₹1797560.2	2022-06-14	Buy
Sigma-Aldrich(India)	SRP2017	GAL4 [(1-147) + VP16 (411-490)] from Saccharomyces cerevisiae human herpesvirus 2 recombinant, expressed in E. coli, ≥80% (SDS-PAGE)	10μG	₹40796.8	2022-06-14	Buy
TCI Chemicals (India)	E0675	Etoposide	1G	₹23400	2022-05-26	Buy
TCI Chemicals (India)	E0675	Etoposide	100MG	₹11500	2022-05-26	Buy
ottokemi	E 7192	Etoposide synthetic, 98.0-105.0%, powder 98%	1gm	₹19494	2022-05-26	Buy
ottokemi	E 7192	Etoposide synthetic, 98.0-105.0%, powder 98%	250mg	₹12906	2022-05-26	Buy
ottokemi	E 7192	Etoposide synthetic, 98.0-105.0%, powder 98%	100mg	₹9594	2022-05-26	Buy
ottokemi	E 7192	Etoposide synthetic, 98.0-105.0%, powder 98%	25mg	₹7605	2022-05-26	Buy

Properties

Melting point :236-251 °C (lit.)
Boiling point :563.9°C (rough estimate)
alpha :D20 -110.5° (c = 0.6 in chloroform)
Density :1.2966 (rough estimate)
refractive index :-110.5 ° (C=0.6, CHCl3)
storage temp. :2-8°C
solubility :DMSO: 30 mg/mL
form :powder
pka :9.8(at 25℃)
color :white
biological source :synthetic
Water Solubility :Insoluble in water.
Merck :14,3886
BCS Class :4
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months
IARC :1 (Vol. 76, 100A) 2012, 1 (Vol. 76, 100A) 2012
EPA Substance Registry System :Etoposide (33419-42-0)

Safety Information

Symbol(GHS):

Signal word:

Danger

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H350	May cause cancer	Carcinogenicity	Category 1A, 1B	Danger
H412	Harmful to aquatic life with long lasting effects	Hazardous to the aquatic environment, long-term hazard	Category 3		P273, P501

Precautionary statements:

P201	Obtain special instructions before use.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P308+P313	IF exposed or concerned: Get medical advice/attention.

Description

Etoposide is a plant alkaloid which acts as an inhibitor of topoisomerase II (IC50 = 60.3 μM). Notably, this compound can have much greater potencies when evaluated in cell-based cytotoxicity assays (e.g., IC50 = 5.14 nM for MCF-7 cells). Etoposide inhibits DNA synthesis by forming a ternary complex with DNA and topoisomerase II, inducing breaks in double stranded DNA. Accumulated breaks in DNA prevent entry into mitosis and lead to cell death. Recent bioassay data suggest that etoposide can also inhibit nuclear receptor coactivator 3 (IC50 = 2.48 μM), a steroid receptor coactivator with histone acetyltransferase activity. Interestingly, histone deacetylase inhibitors can sensitize multidrug-resistant cancer cells to etoposide.

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Suppliers and manufacturers

Medi Pharma Drug House Cipla Ltd Zyphars Biopharmaceuticals Pvt. Ltd Basil Drugs AND Pharmaceuticals Pvt Ltd Sakar Healthcare BDR Pharmaceuticals International Pvt Ltd Aspen Biopharma Labs Pvt Ltd Mac Chem Products (India) Pvt Ltd (Naprod Group) TCI Chemicals (India) Pvt. Ltd. OCEAN TRADING CORPORATION

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