MIF Antagonist, ISO-1
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- ₹4800 - ₹18020
- Product name: MIF Antagonist, ISO-1
- CAS: 478336-92-4
- MF: C12H13NO4
- MW: 235.24
- EINECS:-0
- MDL Number:MFCD22376813
- Synonyms:MIF Antagonist, ISO-1;Methyl 2-(3-(4-hydroxyphenyl)-4,5-dihydroisoxazol-5-yl)acetate;ISO-1;MIF Antagonist;4,5-Dihydro-3-(4-hydroxyphenyl)-5-isoxazoleacetic acid methyl ester;ISO-1 (ISO 1;ISO 1;ISO1;MIF ANTAGONIST;5-Isoxazoleacetic acid, 4,5-dihydro-3-(4-hydroxyphenyl)-, methyl ester
4 prices
Selected condition：
Brand
- TCI Chemicals (India)
- Sigma-Aldrich(India)
Package
- 5MG
- 10MG
- 25MG
- ManufacturerTCI Chemicals (India)
- Product numberI1119
- Product descriptionISO-1
- Packaging5MG
- Price₹4800
- Updated2022-05-26
- Buy
- ManufacturerTCI Chemicals (India)
- Product numberI1119
- Product descriptionISO-1
- Packaging25MG
- Price₹14800
- Updated2022-05-26
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number475837
- Product descriptionMIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem The MIF Antagonist, ISO-1, also referenced under CAS 478336-92-4, controls the biological activity of MIF.
- Packaging5MG
- Price₹14260
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number5.05225
- Product descriptionInSolution MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem
- Packaging10MG
- Price₹18020
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| TCI Chemicals (India) | I1119 | ISO-1 | 5MG | ₹4800 | 2022-05-26 | Buy |
| TCI Chemicals (India) | I1119 | ISO-1 | 25MG | ₹14800 | 2022-05-26 | Buy |
| Sigma-Aldrich(India) | 475837 | MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem The MIF Antagonist, ISO-1, also referenced under CAS 478336-92-4, controls the biological activity of MIF. | 5MG | ₹14260 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 5.05225 | InSolution MIF Antagonist, ISO-1 - CAS 478336-92-4 - Calbiochem | 10MG | ₹18020 | 2022-06-14 | Buy |
Properties
Melting point :114 °C
Boiling point :365.0±48.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO.
pka :9.22±0.30(Predicted)
form :Light yellow crystalline solid.
color :Off-white
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Boiling point :365.0±48.0 °C(Predicted)
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Soluble in DMSO.
pka :9.22±0.30(Predicted)
form :Light yellow crystalline solid.
color :Off-white
Sensitive :Light Sensitive
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety Information
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Description
Macrophage migration inhibitory factor (MIF) is a regulator of inflammation that also has roles in cancer and autoimmune diseases. MIF exhibits both tautomerase and oxidoreductase activities, although how these are linked to MIF’s physiological and pathophysiological actions is unclear. MIF antagonist, also known as ISO-1, is an inhibitor of the dopachrome tautomerase activity of MIF in vitro (IC50 = 7 μM) and in cells (IC50 = 25 μM). It blocks the activation of NF-κB and TNF-α secretion from LPS-treated macrophages and improves the survival of mice following sepsis. MIF antagonist also demonstrates protective effects in airway and gastrointestinal inflammation in mice.More related product prices
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