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NUTLIN-3

NUTLIN-3 Structure
  • ₹10965.73 - ₹42910.3
  • Product name: NUTLIN-3
  • CAS: 548472-68-0
  • MF: C30H30Cl2N4O4
  • MW: 581.49
  • EINECS:200-258-5
  • MDL Number:MFCD07784509
  • Synonyms:(+/-)-4-[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXY-PHENYL)-4,5-DIHYDRO-IMIDAZOLE-1-CARBONYL]-PIPERAZIN-2-ONE;NUTLIN-3;2-Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-;4-[4,5-Bis(4-chlorophenyl)-2-(4-methoxy-2-propan-2-yloxyphenyl)-4,5-dihydroimidazole-1-carbonyl]piperazin-2-one;Piperazinone, 4-[[(4R,5S)-4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-1H-imidazol-1-yl]carbonyl]-, rel-;4-[4,5-Bis-(4-chloro-phenyl)-2-(2-isopropoxy-4-Methoxy-phenyl)-4,5-dihydro-iMidazole-1-carbonyl]-piperazin-2-one;Nutlin-3, >=98%;NUTLIN-3 (Free base)
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberN6287
  • Product descriptionNutlin-3 ≥98% (HPLC), powder
  • Packaging1MG
  • Price₹10965.73
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number444143
  • Product descriptionMDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem The MDM2 Antagonist, Nutlin-3, Racemic, also referenced under CAS 548472-68-0, controls the biological activity of MDM2. This small molecule/inhibitor
  • Packaging1MG
  • Price₹15469.99
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberN6287
  • Product descriptionNutlin-3 ≥98% (HPLC), powder
  • Packaging5MG
  • Price₹42910.3
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) N6287 Nutlin-3 ≥98% (HPLC), powder 1MG ₹10965.73 2022-06-14 Buy
Sigma-Aldrich(India) 444143 MDM2 Antagonist, Nutlin-3, Racemic - CAS 548472-68-0 - Calbiochem The MDM2 Antagonist, Nutlin-3, Racemic, also referenced under CAS 548472-68-0, controls the biological activity of MDM2. This small molecule/inhibitor 1MG ₹15469.99 2022-06-14 Buy
Sigma-Aldrich(India) N6287 Nutlin-3 ≥98% (HPLC), powder 5MG ₹42910.3 2022-06-14 Buy

Properties

Melting point :>132oC (dec.)
Density :1.36±0.1 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: 20 mg/mL, soluble
form :solid
pka :14.35±0.20(Predicted)
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey :BDUHCSBCVGXTJM-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

(+)-Nutlin-3 is a potent inhibitor of p53-Mdm2 interaction.3 (+)-Nutlin-3 is arbitrarily referred to as enantiomer b because it appears as the second peak from chiral purification of racemic nutlin-3 and its absolute stereocenter assignment is not known. It is 150-fold less potent as an inhibitor of p53-Mdm2 interaction than ()-nutlin-3, demonstrating an IC50 value of 13.6 M. This inactive enantiomer can serve as a useful control for non-MDM2 related cellular activities.

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