Tubacin

₹23187.15 - ₹62633.45
Product name: Tubacin
CAS: 537049-40-4
MF: C41H43N3O7S
MW: 721.86
EINECS:
MDL Number:MFCD18452824
Synonyms:Tubacin;N1-(4-((2R,4R,6S)-4-((4,5-diphenyloxazol-2-ylthio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-dioxan-2-yl)phenyl)-N8-hydroxyoctanediamide;N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide Tubacin;N1-[4-[(2R,4R,6S)-4-[[(4,5-diphenyl-2-oxazolyl)thio]methyl]-6-[4-(hydroxymethyl)phenyl]-1,3-dioxan-2-yl]phenyl]-N8-hydroxy-octanediamide;Tubacin, >=98%;N1-(4-((2R,4R,6S)-4-(((4,5-Diphenyloxazol-2-yl)thio)methyl)-6-(4-(hydroxymethyl)phenyl)-1,3-di;BML-GR362;Tubacin (BML-GR362)

Price2 Properties Safety Information Description

2 prices

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Brand

Sigma-Aldrich(India)

Package

ManufacturerSigma-Aldrich(India)
Product numberSML0065
Product descriptionTubacin ≥98% (HPLC)
Packaging1MG
Price₹23187.15
Updated2022-06-14
Buy

ManufacturerSigma-Aldrich(India)
Product numberSML0065
Product descriptionTubacin ≥98% (HPLC)
Packaging5MG
Price₹62633.45
Updated2022-06-14
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	SML0065	Tubacin ≥98% (HPLC)	1MG	₹23187.15	2022-06-14	Buy
Sigma-Aldrich(India)	SML0065	Tubacin ≥98% (HPLC)	5MG	₹62633.45	2022-06-14	Buy

Properties

Melting point :155 - 157°C
storage temp. :-20°C
solubility :DMSO: ≥10mg/mL
form :powder
color :white to tan

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	Pictogram	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning		P264, P270, P301+P312, P330, P501

Precautionary statements:

P280	Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Tubacin is a tubulin acetylation inducer that selectively inhibits histone deacetylase (HDAC) 6 (IC50 = 4 nM). In comparison, it demonstrates at least 300-fold selectivity against all other HDAC isoforms (IC50s range from 1.3-17.3 μM). Tubacin induces α-tubulin hyperacetylation at 2.5 μM in primary cortical neuron cultures. Tubacin inhibition of HDAC6 has been used as a biochemical tool to control microtubule-dependent intracellular trafficking, to manipulate the aggresome formation of misfolded proteins in certain diseases, and to study the dynamics of cellular adhesion.

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