PERHEXILINE MALEATE SALT
- CAS No.
- 6724-53-4
- Chemical Name:
- PERHEXILINE MALEATE SALT
- Synonyms
- Pexid;WSM-3978;WSM 3978G;perhexilinemaleate;perhexilene maleate;rac Perhexiline Maleate;PERHEXILINE MALEATE SALT;PERHEXILINE MALEATE SALT USP/EP/BP;2-(2,2-dicyclohexylethyl)piperidinemaleate;2-(2,2-dicyclohexylethyl)-piperidinmaleate(1:1)
- CBNumber:
- CB1464993
- Molecular Formula:
- C23H39NO4
- Molecular Weight:
- 393.56
- MOL File:
- 6724-53-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/6/30 15:45:59
SAFETY
Risk and Safety Statements
| WGK Germany | 2 |
|---|---|
| RTECS | TM7068000 |
| Toxicity | LD50 in rats, mice (g/kg): >7, 4.37 orally (Causa, Perri) |
PERHEXILINE MALEATE SALT price More Price(2)
PERHEXILINE MALEATE SALT Chemical Properties,Uses,Production
Description
Perhexiline is a carnitine palmitoyltransferase 1 (CPT1) and CPT2 inhibitor that was originally developed as an anti-anginal drug in the 1970s. It inhibits rat heart and liver CPT1 (IC50 = 77 and 148 μM, respectively) and rat heart CPT2 (IC50 = 79 μM). Inhibition of CPT reduces uptake of long-chain fatty acids into the mitochondria, thereby shifting cellular metabolism from β-oxidation to glycolysis. Perhexilin inhibits mTORC1 signaling at 10 μM and induces autophagy ~7-fold at a concentration of 10 μM in MCF-7 cells.
Chemical Properties
White Solid
Uses
PERHEXILINE MALEATE SALT is a Vasodilator, used in treatments for angina.
General Description
Perhexiline maleate regulates?coronary vasodilatation and blocks exercise-induced tachycardia. It is used to treat angina pectoris and variant angina. Perhexiline maleate functions as a cardiac metabolic agent. It is associated with peripheral neuropathy, high intracranial pressure with?papilledema?and proximal myopathy.
Safety Profile
Poison by intraperitoneal route. Moderately toxic by ingestion.Human systemic effects by ingestion: muscle weakness, paresthesia, and hepatitis. Mutation data reported. Whenheated to decomposition it emits toxic fumes of NOx.
PERHEXILINE MALEATE SALT Preparation Products And Raw materials
Raw materials
1of2
chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | United States | 19892 | 58 | Inquiry |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | China | 30253 | 58 | Inquiry |
| ANHUI WITOP BIOTECH CO., LTD | +8615255079626 | China | 23556 | 58 | Inquiry |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | China | 9030 | 58 | Inquiry |
| InvivoChem | +1-708-310-1919 +1-13798911105 | United States | 6393 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | China | 892 | 58 | Inquiry |
| LEAPCHEM CO., LTD. | +86-852-30606658 | China | 43348 | 58 | Inquiry |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | China | 33350 | 58 | Inquiry |
6724-53-4(PERHEXILINE MALEATE SALT)Related Search:
1of4
chevron_right