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ChemicalBook > Product Catalog >API >Synthetic Anti-infective Drugs >Sulfonamides and synergist >(R)-(+)-2-Methyl-2-propanesulfinamide

(R)-(+)-2-Methyl-2-propanesulfinamide

(R)-(+)-2-Methyl-2-propanesulfinamide Structure
CAS No.
196929-78-9
Chemical Name:
(R)-(+)-2-Methyl-2-propanesulfinamide
Synonyms
(R)-2-METHYLPROPANE-2-SULFINAMIDE;(R)-TERT-BUTANESULFINAMIDE;(R)-2-METHYL-2-PROPANESULFINAMIDE;Trityl glycidyl ether;(R)-N-tert-Butanesulfinamide;DASO-002;Borax LR;R-(+)-TBSA;-2-propanesuL;Nicotinamide Impurity 18
CBNumber:
CB2765464
Molecular Formula:
C4H11NOS
Molecular Weight:
121.2
MOL File:
196929-78-9.mol
MSDS File:
SDS
Modify Date:
2024/7/2 9:43:24
Request For Quotation

(R)-(+)-2-Methyl-2-propanesulfinamide Properties

Melting point 103-107 °C(lit.)
Boiling point 220.0±23.0 °C(Predicted)
alpha 4 º (c=1, CHCl3 + amylenes)
Density 0.903 g/mL at 25 °C
refractive index 4 ° (C=1, CHCl3)
Flash point -17℃
storage temp. 2-8°C
solubility Soluble in chloroform, methanol, tetrahydrofuran, dichloromethane, dimethyl sulfoxide and most organic solvents.
form Powder
pka 10.11±0.50(Predicted)
color White, light pink, light yellow to brown
optical activity [α]22/D +1.0°, c = 0.5% in chloroform
Stability store cold
InChIKey CESUXLKAADQNTB-SSDOTTSWSA-N
CAS DataBase Reference 196929-78-9(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS02,GHS07,GHS08
Signal word  Danger
Hazard statements  H225-H302-H319-H335-H351
Precautionary statements  P210-P280-P301+P312+P330-P305+P351+P338-P370+P378-P403+P235
Hazard Codes  Xi,Xn,F
Risk Statements  11-19-36/37-40-36/37/38
Safety Statements  22-24/25-36/37-26-16-36/37/39
RIDADR  UN 2056 3 / PGII
WGK Germany  3
Hazard Note  Irritant/Keep Cold
TSCA  No
HS Code  29309090
NFPA 704
1
2 0

(R)-(+)-2-Methyl-2-propanesulfinamide price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich(India) 737941 (R)-(+)-2-Methyl-2-propanesulfinamide solution 1?M in THF, contains BHT as inhibitor 196929-78-9 10ML ₹1569.4 2022-06-14 Buy
Sigma-Aldrich(India) 737941 (R)-(+)-2-Methyl-2-propanesulfinamide solution 1?M in THF, contains BHT as inhibitor 196929-78-9 50ML ₹3896.9 2022-06-14 Buy
Sigma-Aldrich(India) 497401 (R)-(+)-2-Methyl-2-propanesulfinamide 98% 196929-78-9 1G ₹5564.05 2022-06-14 Buy
Sigma-Aldrich(India) 497401 (R)-(+)-2-Methyl-2-propanesulfinamide 98% 196929-78-9 5G ₹12665.25 2022-06-14 Buy
Sigma-Aldrich(India) 497401 (R)-(+)-2-Methyl-2-propanesulfinamide 98% 196929-78-9 25G ₹47597.53 2022-06-14 Buy
Product number Packaging Price Buy
737941 10ML ₹1569.4 Buy
737941 50ML ₹3896.9 Buy
497401 1G ₹5564.05 Buy
497401 5G ₹12665.25 Buy
497401 25G ₹47597.53 Buy

(R)-(+)-2-Methyl-2-propanesulfinamide Chemical Properties,Uses,Production

Chemical Properties

(R)-(+)-2-Methyl-2-propanesulfinamide is white to light yellow crystal powde

Uses

(R)-(+)-2-Methyl-2-propanesulfinamide is a chiral ligand, which is used in pharmaceutical compositions. Further, it is used in the preparation of beta-chloro sulfinamides in the synthesis of chiral azridines. It is involved in the preparation of organocatalyst for enantioselective reduction of imines. It serves as a reagent for synthesizing chiral amines. In addition to this, it is converted into P,N-sulfinyl imine ligands through condensation with aldehydes and ketones which undergoes iridium-catalyzed asymmetric hydrogenation of olefins.

Preparation

Acetic acid (70 g), R-tert-butylsulfinylhydrazine (42 g), zinc powder (60.5 g) and dichloromethane (150 mL) were added to the reaction flask. The temperature was slowly heated to 35-42 °C . After 16 hours, the filtrate was poured into 70 mL water. Dichloromethane (75 g×5) was added for extraction. Collected the organic phase, added 48% NaOH to adjust ρΗ (7-8). Then added NaCl, the layers were separated and the organic phase was washed with 15 g saturated aqueous solution of sodium chloride. The solution was dried over magnesium sulfate. After filterED, filtrate was concentrated under reduced pressure at 25-30 °C until no slipping. N-heptane was replaced, 28 g mixed solvent of N-heptane and toluene (N-heptane: toluene = 6:1) were added to perform beating at low temperature, filtered to obtain (R)-(+)-2-Methyl-2-propanesulfinamide. Yield=83%
(R)-( )-2-Methyl-2-propanesulfinamide

References

[1] Qian X, et al. A stereoselective synthesis of (S)-2-(((3-fluoro-4-methylphenoxy)carbonyl)(1-(4-((5-methyl-2-phenyloxazol-4-yl)methoxy)phenyl)ethyl)amino)acetic acid, a highly potent PPAR α/γ dual agonist. Tetrahedron, 2015; 71: 9408-9414.

(R)-(+)-2-Methyl-2-propanesulfinamide Preparation Products And Raw materials

Raw materials

Vanadyl acetylacetonate 2-Chloro-2-methylpropane Hydrogen peroxide Sodium sulfate (S)-TERT-LEUCINOL
3,5-Di-tert-butylsalicylaldehyde Sulfur dioxide Potassium carbonate Ferric nitrate Triethylamine
(R)-(+)-1-Phenylethylamine Palladium Di-tert-butyl disulfide L-1-Phenylethylamine Tetrahydrofuran
Diethyl ether Ammonium chloride Ethyl acetate Hydrochloric acid Dichloromethane
Methanol Thionyl chloride PETROLEUM ETHER Magnesium Lithium
Sulfuric acid Ammonia
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Preparation Products

(R)-(+)-2-Methyl-2-propanesulfinamide Suppliers

Global( 460)Suppliers
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JIVICHEM SYNTHESIS PVT LTD +91-7028392790 +91-7028392790 Maharashtra, India 337 58 Inquiry
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VIVAN Life Sciences Pvt. Limited. +91(22) 2544 4584 / 2544 4585 New Delhi, India 138 50 Inquiry
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CHEMSWORTH +91-261-2397244 New Delhi, India 6707 30 Inquiry
CLEARSYNTH LABS LTD. +91-22-45045900 Hyderabad, India 6351 58 Inquiry
Supplier Advantage
JIVICHEM SYNTHESIS PVT LTD 58
Biosyn Research Chemicals 58
ssk bioscience pvt. ltd 58
Aravali Pharma And Lifesciences 58
GLR Innovations 58
SL Drugs and Pharmaceuticals Pvt. Ltd. 50
VIVAN Life Sciences Pvt. Limited. 50
A.J Chemicals 58
CHEMSWORTH 30
CLEARSYNTH LABS LTD. 58

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R- tert butyl sulfenaMide (R)-(+)-TERT-BUTANESULFINAMIDE (R)-(+)-T-BUTANESULFINAMIDE (R)-(+)-T-BUTYLMETHYLSULFINAMIDE (R)-(+)-T-BUTYLSULFINAMIDE (R)-(+)-TERT-BUTYLSULFINAMIDE (R)-(+)-TERT-BUTYL SULPHINAMIDE (R)-(+)-2-METHYL-PROPANE-2-SULFINIC ACID AMIDE (R)-(+)-2-METHYL-2-PROPANESULFINAMIDE (R)- (+)- 2-Methyl-2-propanesulphinaMide (R)-(+)-2-Methyl-2-propanesulfinaMide / (R)-tert-ButanesulfinaMide (R)-(+)-2-Methyl-2-propanesulfinamide solution 2-Propanesulfinamide, 2-methyl-, [S(R)]- (R)-(+)-tert-Butylsulfinamide (R)-(+)-2-Methyl-2-propanesulfinaMide, 97+% (R)-(+)-2-Methyl-2-propanesulfinamide 98% (R)-(+)-2-Methyl-2-propanesulfinamide≥ 99% (HPLC, Chiral purity) (R)-2-Methyl-2-propanesulfinamide,99%e.e. (R)-TERT-BUTANESULFINAMIDE / (R)-(+)-2-METHYL-2-PROPANESULFINAMIDE (R)-(+)-2-METHYL-2-PROPANESULFINAMIDE, 98+% R-(+)-Tert-Butansulfinamide (R)-(+)-t-Butylmethylsulfinamide,min.97% (R)-(+)-tert-Butyl sulphinamide 98% (R)-(+)-t-Butyl sulfinamide, 98% ee (R)-(+)-2-Methylpropane-2-sulphinamide (R)-(+)-t-Butylmethylsulfinamide, min. 97% (R)-(+)-Methyl-2-propanesulfinamide (R)-(+)-2-Methylpropane-2-sulphinamide 98% R-(+)-TBSA (R)-(+)-t-Butylsulfinamide, min. 97% (R)-(+)-2-methyyl-2-propanesulfinamide DASO-002 (R)-(+)-tert-Butylsulfinamide > -2-propanesuL (R)-(+) -tert-butylsulfonamide (R)-(+)-2-Methyl-2-propanesulfinamide USP/EP/BP (R)-(-)-2-Methyl-2-Propane sulfonamide (R)-TERT-BUTANESULFINAMIDE (R)-2-METHYLPROPANE-2-SULFINAMIDE (R)-2-METHYL-2-PROPANESULFINAMIDE Trityl glycidyl ether (R)-N-tert-Butanesulfinamide RSYY（Donepezil Hydrochloride)-8 Nicotinamide Impurity 18 Borax LR S-(tert-butyl) (R)-2-methylpropane-2-sulfinothioate 196929-78-9 1969-78-9 96929-78-9 3196929-78-9 C6H19NOS C4H11OSN Chiral Auxiliaries Asymmetric Synthesis Sulfur-Based Synthetic Organic Chemistry CHIRAL CHEMICALS Sulfur Compounds