3,5,5-TRIMETHYLOXAZOLIDINE-2,4-DIONE
- CAS No.
- 127-48-0
- Chemical Name:
- 3,5,5-TRIMETHYLOXAZOLIDINE-2,4-DIONE
- Synonyms
- a2297;Edion;A 2297;Epixal;Pitmal;Ptimal;Absetil;Epidone;Etydion;Petidon
- CBNumber:
- CB3477704
- Molecular Formula:
- C6H9NO3
- Molecular Weight:
- 143.14
- MOL File:
- 127-48-0.mol
- Modify Date:
- 2024/7/2 8:55:06
| Melting point | 45-46°C |
|---|---|
| Boiling point | 78-80°C 5mm |
| Density | 1.3075 (rough estimate) |
| refractive index | 1.4290 (estimate) |
| Flash point | 78-80°C/5mm |
| storage temp. | Inert atmosphere,Room Temperature |
| solubility | Soluble in water, very soluble in ethanol (96 per cent). |
| pka | -2.18±0.40(Predicted) |
| form | Solid |
| color | White to Off-White |
| Water Solubility | Soluble in water 50 g/L. |
| Merck | 14,9706 |
| BRN | 121627 |
| CAS DataBase Reference | 127-48-0(CAS DataBase Reference) |
| EPA Substance Registry System | Trimethadione (127-48-0) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H312+H332-H360 | |||||||||
| Precautionary statements | P201-P280-P302+P352+P312-P304+P340+P312-P308+P313 | |||||||||
| Hazard Codes | T | |||||||||
| Risk Statements | 61-20/21/22 | |||||||||
| Safety Statements | 53-22-36/37/39-45 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | RQ2100000 | |||||||||
| NFPA 704 |
|
3,5,5-TRIMETHYLOXAZOLIDINE-2,4-DIONE Chemical Properties,Uses,Production
Chemical Properties
White, granular, crystalline substance; camphor-like odor. Soluble in water; freely soluble in alcohol, chloroform, and ether; pH 6.0 (5% solution).
Uses
3,5,5-Trimethyloxazolidine-2,4-dione is used in the control of absence (petit mal) seizures that are refractory to treatment with other medications. It is used in the treatment of epilepsy.
brand name
Absentol (Nourypharma), Epidione (Bellon), Ptimal (EGIS), Tridione/Trimedone (Abbott).
Hazard
May have adverse side effects; toxic in overdose.
Clinical Use
Trimethadione is indicated only for control of absence seizures refractory to treatment with other AEDs. It is ineffective against other seizure types. Trimethadione is a pro-drug and is metabolized by N-demethylation to dimethadione, which is effective in the pentylenetetrazole test, which acts by decreasing T-type calcium currents. Trimethadione is rapidly absorbed, is not protein bound, and has a half-life of 16 to 24 hours. The half-life of dimethadione, however, is substantially longer (i.e., 6–13 days), and dimethadione accumulates to concentrations greater than the parent drug. Because of its potentially fatal side effects. including aplastic anemia, nephrosis, idiosyncratic rashes, and exfoliative dermatitis, trimethadione rarely is used today.
3,5,5-TRIMETHYLOXAZOLIDINE-2,4-DIONE Preparation Products And Raw materials
Raw materials
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3,5,5-TRIMETHYLOXAZOLIDINE-2,4-DIONE Suppliers
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