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SULFAPHENAZOLE

CAS No.: 526-08-9

Chemical Name:: SULFAPHENAZOLE

Synonyms: SP;TFF2;Sulfabid;Sulfaphenazol;Sulphaphenazole;Sulfaphenylpyrazole;SML1;Orisul;Inamil;Isarol

CBNumber:: CB4160540

Molecular Formula:: C15H14N4O2S

Molecular Weight:: 314.36

MOL File:: 526-08-9.mol

MSDS File:: SDS

Modify Date:: 2023/5/18 11:31:06

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SULFAPHENAZOLE Properties

Melting point	179-183 °C
Boiling point	541.9±56.0 °C(Predicted)
Density	1.39
refractive index	1.6440 (estimate)
storage temp.	2-8°C
solubility	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
form	Solid
pka	pKa 5.71(H2O t = 25 I = 0.05) (Uncertain)
color	white to light yellow

SAFETY

Risk and Safety Statements

Safety Statements	24/25
WGK Germany	2
RTECS	DA9520000
HS Code	29339900
Toxicity	LD50 orally in mice: 5800 mg/kg (Seki)

SULFAPHENAZOLE price More Price(5)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	UC166	Sulfaphenazole ≥98% (HPLC)	526-08-9	5MG	₹61440	2022-06-14	Buy
Sigma-Aldrich(India)	UC166	Sulfaphenazole ≥98% (HPLC)	526-08-9	10MG	₹111630	2022-06-14	Buy
Sigma-Aldrich(India)	S0758	Sulfaphenazole ≥98%	526-08-9	1G	₹30230	2022-06-14	Buy
Sigma-Aldrich(India)	SRP4745	TFF-2 human recombinant, expressed in E. coli, ≥98% (SDS-PAGE), ≥98% (HPLC)	526-08-9	20μG	₹34477.2	2022-06-14	Buy
Sigma-Aldrich(India)	S0758	Sulfaphenazole ≥98%	526-08-9	5X1G	₹118533.75	2022-06-14	Buy

Product number	Packaging	Price	Buy
UC166	5MG	₹61440	Buy
UC166	10MG	₹111630	Buy
S0758	1G	₹30230	Buy
SRP4745	20μG	₹34477.2	Buy
S0758	5X1G	₹118533.75	Buy

SULFAPHENAZOLE Chemical Properties,Uses,Production

Description

CYP2C9 is a major cytochrome P450 enzyme that is involved in the metabolic clearance of various therapeutic agents. Disruption of this enzyme’s activity can lead to adverse drug reactions. Sulfaphenazole is an inhibitor of CYP2C9 (K_i = 0.3 μM) that demonstrates at least 100-fold selectivity over other CYP450 isoforms (K_is = 63 and 29 μM for CYP2C8 and CYP2C18, respectively, and no activity at CYP1A1, CYP1A2, CYP3A4, CYP2C19). At 10 μM, sulfaphenazole has been shown to inhibit endothelium-derived hyperpolarizing factor synthase, a CYP450 isozyme in the porcine coronary artery homologous to CYP2C8/9 that generates reactive oxygen species in coronary endothelial cells and modulates vascular tone and homeostasis.

Chemical Properties

White to off-white powder

Definition

ChEBI: A sulfonamide that is sulfanilamide in which the sulfonamide nitrogen is substituted by a 1-phenyl-1H-pyrazol-5-yl group. It is a selective inhibitor of cytochrome P450 (CYP) 2C9 isozyme, and antibacterial agent.

Purification Methods

Crystallise it from EtOH or aqueous EtOH. [Schmidt & Druey Helv Chim Acta 41 309 1958, Beilstein 25 III/IV 2029.]

SULFAPHENAZOLE Preparation Products And Raw materials

Raw materials

Sodium dithionite Ethanol Triethyl orthoformate 5-AMINO-1-PHENYLPYRAZOLE Chlorosulfonic acid

Ethyl acetate Hydrochloric acid Sodium hydroxide Thionyl chloride 4-NITROBENZENESULFONIC ACID

Phenylhydrazine PETROLEUM ETHER PHENYLURETHANE Ethyl cyanoacetate

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Preparation Products

SULFAPHENAZOLE Suppliers

Global( 166)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
Pharmaffiliates Analytics and Synthetics P. Ltd	+91-172-5066494	Haryana, India	6773	58	Inquiry
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	China	32760	60	Inquiry
CONIER CHEM AND PHARMA LIMITED	+8618523575427	China	49391	58	Inquiry
career henan chemical co	+86-0371-86658258 +8613203830695	China	29826	58	Inquiry
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	China	24639	58	Inquiry
AFINE CHEMICALS LIMITED	+86-0571-85134551	China	15395	58	Inquiry
InvivoChem	+1-708-310-1919 +1-13798911105	United States	6393	58	Inquiry
TargetMol Chemicals Inc.	+1-781-999-5354	United States	19973	58	Inquiry

Supplier	Advantage
CLEARSYNTH LABS LTD.	58
A.J Chemicals	58
Pharmaffiliates Analytics and Synthetics P. Ltd	58
ATK CHEMICAL COMPANY LIMITED	60
CONIER CHEM AND PHARMA LIMITED	58
career henan chemical co	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58
InvivoChem	58
TargetMol Chemicals Inc.	58

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LABOTEST-BB LT00772280 4-AMINO-N-(1-PHENYL-1H-PYRAZOL-5-YL)BENZENESULFONAMIDE n(sup1)-(1-phenylpyrazol-5-yl)sulfanilamide n’-(1-phenylpyrazol-5-yl)sulfanilamide N¹-(1-Phenylpyrazol-5-yl)sulfanilamide Orisul Orisulf Paidazolo Plisulfan Raziosulfa Sulfafenazolo Sulfanilamide, N¹-(1-phenylpyrazol-5-yl)- Sulfaphenazon Sulfaphenylpipazol Sulphenazole SULFAPHENAZOLE Eftolan Sulfiam 4-amino-N-(2-phenylpyrazol-3-yl)benzenesulfonamide 4-azanyl-N-(2-phenylpyrazol-3-yl)benzenesulfonamide Sulfaphenazole ,99% Sulfaphenazole,4-Amino-N-(1-phenyl-1H-pyrazol-5-yl)benzenesulfonamide N1-(1-phenylpyrazol-5-yl)sulphanilamide SULFAPHENZAOLE N1-(1-Phenylpyrazol-5-yl)sulfanilamide Sulfaphenazole Solution, 100ppm pS2 protein 1-Phenyl-5-sulfanilamidopyrazole 3-(p-Aminobenzenesulfonamido)-2-pheny-2H-lpyrazole 3-(p-aminobenzenesulfonamido)-2-phenylpyrazole 4-amino-n-(1-phenyl-1h-pyrazol-5-yl)-benzenesulfonamid 5-Sulfanilamido-1-phenylpyrazole Benzenesulfonamide, 4-amino-N-(1-phenyl-1H-pyrazol-5-yl)- Depocid Depotsulfonamide Eftolon Firmazolo Inamil Isarol Isarol V Merian Microtan pirazolo microtanpirazolo N'-(1-Phenylpyrazol-5-yl)sulfanilamide n(sup1)-(1-phenylpyrazol-5-yl)-sulfanilamid TFF-2 human Trefoil Factor peptide SML1 Spasmolytic polypeptide Trefoil factor 2 4-amino-N-(2-phenyl-3-pyrazolyl)benzenesulfonamide N1-(1-Phenylpyraz Sulfaphenazole - Depocid | Depotsulfonamide | Plisulfan | Raziosulfa aesculi coniospora sp. JSM071073 sp. L-1 sp. S13