Thimerosal
- CAS No.
- 54-64-8
- Chemical Name:
- Thimerosal
- Synonyms
- THIOMERSAL;MERTHIOLATE;THIMEROSOL;cas no.:54-64-8;MERTHIOLATE SODIUM;elicide;merfamin;merzonin;THIMERSOL;mertorgan
- CBNumber:
- CB4227430
- Molecular Formula:
- C9H9HgNaO2S
- Molecular Weight:
- 404.81
- MOL File:
- 54-64-8.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/12/28 14:47:57
| Melting point | 234-237 °C (dec.)(lit.) |
|---|---|
| Flash point | 250 °C |
| storage temp. | Store at RT. |
| solubility | methanol: 0.1 g/mL, ≤ 10 TE CF |
| form | Powder |
| color | white to off-white |
| PH | 6.0～8.0 (10g/L, 25℃) |
| Water Solubility | 1 G/ML (20 ºC) |
| Merck | 13,9389 |
| BRN | 8169555 |
| Stability | Stable. May degrade in sunlight. Incompatible with strong acids, strong bases, strong oxidizing agents, iodine, heavy metal salts. |
| InChI | InChI=1S/C7H6O2S.C2H4.Hg.Na/c8-7(9)5-3-1-2-4-6(5)10;1-2;;/h1-4,10H,(H,8,9);1H,2H3;;/q;-1;2*+1/p-1 |
| InChIKey | RTKIYNMVFMVABJ-UHFFFAOYSA-L |
| SMILES | O=C1[O-][Hg+2]([CH-]C)[SH-]C2=CC=CC=C12.[Na+] |
| CAS DataBase Reference | 54-64-8(CAS DataBase Reference) |
| EPA Substance Registry System | Thimerosal (54-64-8) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |    GHS06,GHS08,GHS09 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Danger | |||||||||
| Hazard statements | H300+H310+H330-H373-H410 | |||||||||
| Precautionary statements | P262-P273-P280-P302+P352+P310-P304+P340+P310-P314 | |||||||||
| Hazard Codes | T+,N,T | |||||||||
| Risk Statements | 26/27/28-33-50/53 | |||||||||
| Safety Statements | 13-28-36-45-60-61-28A | |||||||||
| RIDADR | UN 2025 6.1/PG 3 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | OV8400000 | |||||||||
| F | 8 | |||||||||
| TSCA | Yes | |||||||||
| HazardClass | 6.1(b) | |||||||||
| PackingGroup | III | |||||||||
| HS Code | 29310095 | |||||||||
| Toxicity | LD50 s.c. in rats: 98 mg/kg (Mason) | |||||||||
| NFPA 704 |
|
Thimerosal price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T5125 | Thimerosal 97.0-101.0% (on dried substance, titration) | 54-64-8 | 10G | ₹14786.95 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T5125 | Thimerosal 97.0-101.0% (on dried substance, titration) | 54-64-8 | 25G | ₹29227.5 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T5125 | Thimerosal 97.0-101.0% (on dried substance, titration) | 54-64-8 | 100G | ₹93733.68 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T5125 | Thimerosal 97.0-101.0% (on dried substance, titration) | 54-64-8 | 500G | ₹357885.33 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T4687 | Thimerosal meets USP testing specifications | 54-64-8 | 25G | ₹32734.8 | 2022-06-14 | Buy |
Thimerosal Chemical Properties,Uses,Production
Chemical Properties
Thimerosal is a light cream-colored crystalline powder with a slight, characteristic odor.
Uses
Thimerosal is used as ophthalmie preservative; topieal anti-infective; topical veterinary antibacterial and antifungal agent; bacteriostat; fungistat; preservative in vaccines, antitoxins, skin-testing allergens, antiseptics, contact-Iens solutions, and cosmetic products like eye makeup.
Production Methods
Thimerosal is prepared by the interaction of ethylmercuric chloride, or hydroxide, with thiosalicylic acid and sodium hydroxide, in ethanol (95%).
Definition
ChEBI: An alkylmercury compound (approximately 49% mercury by weight) used as an antiseptic and antifungal agent.
General Description
Light cream-colored crystalline powder with a slight odor: pH (1% aqueous solution) 6.7. Slight odor.
Air & Water Reactions
Water soluble.
Reactivity Profile
Thimerosal is incompatible with strong oxidizing agents and strong bases. The oxidation of Thimerosal is greatly accelerated by traces of copper ions. Incompatible with acids, iodine, heavy metal salts and many alkaloids. Can be absorbed by rubber caps. . Stable in air, but not sunlight. May discolor on exposure to light. Dilute aqueous solutions are fairly stable to heat but sensitive to light. Solutions are less stable to heat when acidic than when alkaline. Solutions are most stable to light at pH 5 to 7. Solutions are unstable to heat but not to light in the presence of copper, iron or zinc ions but not in the presence of calcium or magnesium ions.
Hazard
Toxic by ingestion, inhalation.
Fire Hazard
Flash point data for Thimerosal are not available; however, Thimerosal is probably combustible.
Pharmaceutical Applications
Thimerosal has been used as an antimicrobial preservative in
biological and pharmaceutical preparations since the 1930s.
It is used as an alternative to benzalkonium chloride and other
phenylmercuric preservatives, and has both bacteriostatic and
fungistatic activity. Increasing concerns over its safety have,
however, led to questions regarding its continued use in formulations.
Thimerosal is also used in cosmetics and to
preserve soft contact lens solutions.
Therapeutically, thimerosal is occasionally used as a bacteriostatic
and fungistatic mercurial antiseptic, which is usually applied
topically at a concentration of 0.1% w/w. However, its use is
declining owing to its toxicity and effects on the environment.
Contact allergens
Thiomersal is an organic mercury salt prepared by react- ing ethylmercuric chloride (or ethylmercuric hydroxide) with thiosalicylic acid. It is still used as a disinfectant and a preservative agent, but less commonly than previ- ously, especially in contact lens fluids, eyedrops, and vaccines. The ethylmercuric moiety is the major aller- genic determinant, sometimes associated with mercury sensitivity. Thiomersal is an indicator of photosensitiv- ity to piroxicam, through its thiosalicylic moiety.
Safety Profile
Poison by ingestion, subcutaneous, and intravenous routes. Experimental teratogenic and reproductive effects. An eye irritant. Questionable carcinogen with experimental neoplastigenic data. Mutation data reported. An ophthalmic preservative, a topical anti-infective, topical veterinary antibacterial and antifungal agent. An FDA over-the-counter drug. When heated to decomposition it emits very toxic fumes of Hg, Na2O, and SOx. See also MERCURY COMPOUNDS.
Environmental Fate
Thimerosal is a cream-colored crystalline powder; it is water soluble and thus the compound can leach into groundwater. Aquatic toxicity has been demonstrated at relatively high concentrations.
storage
Thimerosal is stable at normal temperatures and pressures;
exposure to light may cause discoloration.
Aqueous solutions may be sterilized by autoclaving but are
sensitive to light. The rate of oxidation in solutions is increased by
the presence of trace amounts of copper and other metals. Edetic
acid or edetates may be used to stabilize solutions but have been
reported to reduce the antimicrobial efficacy of thimerosal
solutions.
The solid material should be stored in a well-closed container,
protected from light, in a cool, dry place.
Purification Methods
Recrystallise this antibacterial from EtOH/Et2O. HIGHLY TOXIC. [Trikojus Nature 158 472 1940, Beilstein 10 III 213.]
Incompatibilities
Incompatible with aluminum and other metals, strong oxidizing
agents, strong acids and bases, sodium chloride solutions,
lecithin, phenylmercuric compounds, quaternary ammonium compounds,
thioglycolate, and proteins. The presence of sodium
metabisulfite, edetic acid, and edetates in solutions can reduce the
preservative efficacy of thimerosal.
In solution, thimerosal may be adsorbed by plastic packaging
materials, particularly polyethylene. It is strongly adsorbed by
treated or untreated rubber caps that are in contact with
solutions.
When it was used with cyclodextrin, the effectiveness of
thimerosal was reduced; however, this was related to the lipid
nature of the other ingredients in the preparation.
Regulatory Status
Included in the FDA Inactive Ingredients Database (IM, IV, and SC injections; ophthalmic, otic, and topical preparations). Included in nonparenteral and parenteral medicines licensed in the UK. In the UK, the use of thimerosal in cosmetics is limited to 0.003% w/w (calculated as mercury) as a preservative in shampoos and haircreams, which contain nonionic emulsifiers that would render other preservatives ineffective. The total permitted concentration (calculated as mercury) when mixed with other mercury compounds is 0.007% w/w. Included in the Canadian List of Acceptable Nonmedicinal Ingredients.
Thimerosal Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| JSK Chemicals | +919879767970 | Gujarat, India | 3756 | 58 | Inquiry |
| Syglak Laboratories Pvt Ltd | +91-7506010127 +91-7506010127 | Maharashtra, India | 17 | 58 | Inquiry |
| CJEX Biochem Pvt Ltd | +91-2222033022 +91-2222033022 | Maharashtra, India | 17 | 58 | Inquiry |
| OCEAN TRADING CORPORATION | +91(22) 24921669 | New Delhi, India | 6211 | 58 | Inquiry |
| shrenik pharma ltd | 91-22831012 | New Delhi, India | 13 | 47 | Inquiry |
| Maas Pharma Chemicals | +91-9958666224 | Delhi, India | 1607 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Otto Chemie Pvt. Ltd. | +91 9820041841 | Mumbai, India | 5873 | 58 | Inquiry |
| CHEMSWORTH | +91-261-2397244 | New Delhi, India | 6707 | 30 | Inquiry |
| FINAR LTD | +91 - 2717 - 616717 | New Delhi, India | 660 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| JSK Chemicals | 58 |
| Syglak Laboratories Pvt Ltd | 58 |
| CJEX Biochem Pvt Ltd | 58 |
| OCEAN TRADING CORPORATION | 58 |
| shrenik pharma ltd | 47 |
| Maas Pharma Chemicals | 58 |
| CLEARSYNTH LABS LTD. | 58 |
| Otto Chemie Pvt. Ltd. | 58 |
| CHEMSWORTH | 30 |
| FINAR LTD | 58 |