Esmolol
- CAS No.
- 81147-92-4
- Chemical Name:
- Esmolol
- Synonyms
- ESMOLOL;asl8052-001;(+-)-Esmolol;Methyl 3-[4-(2-hydroxy-3-propan-2-ylamino-propoxy)phenyl]propanoate;Methyl 4-[2-hydoxy-3[(1-methylethyl)amino]-propoxy]benzenepropanoate;methyl4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)benzenepropanoate;4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)-benzenepropanoicacimethyle;Methyl 3-[4-({2-hydroxy-3-[(1-methylethyl)amino]propyl}oxy)phenyl]propanoate;3-[4-[2-Hydroxy-3-(isopropylamino)propoxy]phenyl]propanoic acid methyl ester;3-[4-(2-Hydroxy-3-isopropylamino-propoxy)-phenyl]-propionic acid methyl ester
- CBNumber:
- CB6454935
- Molecular Formula:
- C16H25NO4
- Molecular Weight:
- 295.37
- MOL File:
- 81147-92-4.mol
- MSDS File:
- SDS
- Modify Date:
- 2023/5/21 10:59:17
| Melting point | 48-50 °C |
|---|---|
| Boiling point | 430.2±40.0 °C(Predicted) |
| Density | 1.026 |
| storage temp. | Store at -20°C |
| solubility | DMSO: 59 mg/mL (199.75 mM);Ethanol: 59 mg/mL (199.75 mM) |
| pka | 13.88±0.20(Predicted) |
| Water Solubility | Slightly soluble |
| Merck | 14,3700 |
| CAS DataBase Reference | 81147-92-4(CAS DataBase Reference) |
Esmolol Chemical Properties,Uses,Production
Uses
Esmolol is a cardioselective beta1 receptor blocking agent.
Hazard
A reproductive hazard.
Clinical Use
Esmolol (Brevibloc) is a short-acting intravenously administered
β1-selective adrenoceptor blocking agent. It
does not possess membrane-stabilizing activity or sympathomimetic
activity.
Esmolol is used in the treatment of supraventricular
tachyarrhythmias for rapid control of ventricular rate
and reduction of myocardial oxygen consumption.
Discontinuation of administration is followed by a rapid
reversal of its pharmacological effects because of esmolol’s
rapid hydrolysis by plasma esterases.
Side effects
The most frequently reported adverse effects are hypotension, nausea, dizziness, headache, and dyspnea.As with many β-blocking drugs, esmolol is contraindicated in patients with overt heart failure and those in cardiogenic shock.
Metabolism
The -blocker esmolol (Brevibloc) is unusual in that it is very rapidly metabolized; its plasma half-life is only 9 minutes. It is subject to hydrolysis by cytosolic esterases in red blood cells to yield methanol and an acid metabolite, the latter having an elimination half-life of about 4 hours. Only 2% of the administered esmolol is excreted unchanged. Because of its rapid onset and short duration of action, esmolol is used by the intravenous route for the control of ventricular arrhythmias in emergencies.
Esmolol Preparation Products And Raw materials
Raw materials
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Esmolol Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| TCI Chemicals (India) Pvt. Ltd. | 1800 425 7889 | New Delhi, India | 6778 | 58 | Inquiry |
| Pharmaffiliates Analytics and Synthetics P. Ltd | +91-172-5066494 | Haryana, India | 6773 | 58 | Inquiry |
| MANGALAM DRUGS AND ORGANICS LIMITED | 08147509329 | Uttar Pradesh, India | 50 | 58 | Inquiry |
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| SynZeal Research Pvt Ltd | +1 226-802-2078 | Gujarat, India | 6522 | 58 | Inquiry |
| Daga Global Chemicals Pvt., Ltd. (DGCPL) | 91-22-28920909 | Maharashtra, India | 14 | 58 | Inquiry |
| GLOBAL CALCIUM PRIVATE LTD | 91-80-40554500 | New Delhi, India | 34 | 58 | Inquiry |
| Shivam Pharma Chemicals | 91-22-26403900 | Maharashtra, India | 656 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| ShanDong Look Chemical Co.,Ltd. | +8617653113219 | China | 2739 | 58 | Inquiry |
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