1 NM-PP1
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- ₹10310 - ₹15469.99
- Product name: 1 NM-PP1
- CAS: 221244-14-0
- MF: C20H21N5
- MW: 331.41
- EINECS:
- MDL Number:MFCD03425470
- Synonyms:4-AMINO-1-TERT-BUTYL-3-(1'-NAPHTHYLMETHYL)PYRAZOLO[3,4-D]PYRIMIDINE;4-AMINO-1-TERT-BUYTL-3-(1-NAPHTHYLMETHYL)PYRAZOLO[3,4-D]PYRIMIDINE;1 NM-PP1;MUTANT KINASES INHIBITOR II;PP1 ANALOG II;1-(1,1-Dimethylethyl)-3-(1-naphthalenylmethyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1-tert-Butyl-3-(naphthalen-1-ylmethyl)-1H-pyrazolo[3,4-D]pyrimidin-4-amine;Chebi:52309
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- ManufacturerSigma-Aldrich(India)
- Product number529606
- Product descriptionInSolution PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem
- Packaging1MG
- Price₹10310
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number529581
- Product descriptionPP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem PP1 Analog II, CAS 221244-14-0, is a cell-permeable PP1 analog that acts as a potent, reversible, selective, ATP-competitive inhibitor of mutant over
- Packaging1MG
- Price₹15469.99
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 529606 | InSolution PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem | 1MG | ₹10310 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 529581 | PP1 Analog II, 1NM-PP1 - CAS 221244-14-0 - Calbiochem PP1 Analog II, CAS 221244-14-0, is a cell-permeable PP1 analog that acts as a potent, reversible, selective, ATP-competitive inhibitor of mutant over | 1MG | ₹15469.99 | 2022-06-14 | Buy |
Properties
Melting point :175-176°C
Boiling point :545.7±45.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Chloroform (Slightly), Methanol (Slightly, Heated)
pka :4.50±0.30(Predicted)
form :White solid
color :White to Beige
Boiling point :545.7±45.0 °C(Predicted)
Density :1.25±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :Chloroform (Slightly), Methanol (Slightly, Heated)
pka :4.50±0.30(Predicted)
form :White solid
color :White to Beige
Safety Information
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Description
1-NM-PP1 is a cell permeable inhibitor of kinases that have been mutated, by a single base substitution, to become ‘analog sensitive’ (as), as compared to the wild-type kinase. 1-NM-PP1 was first developed to optimally inhibit v-Src-as1, with an I338G substitution, preferentially over v-Src (IC50 = 4.2 nM versus 28 μM, respectively). The homologous mutation in other kinases generated similar analog sensitivity (e.g., IC50 = 3.2 nM for c-Fyn-as1 versus 1.0 μM for c-Fyn; 5.0 nM for Cdk2-as1 versus 29 μM for Cdk2; 8.0 nM for CAMKII-as1 versus 24 μM for CAMKII). This approach has been used to elucidate functions of several kinases in both mammalian and yeast systems.More related product prices
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