7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde
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- ₹11420.38 - ₹46515.03
- Product name: 7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde
- CAS: 14003-96-4
- MF: C11H8O4
- MW: 204.18
- EINECS:
- MDL Number:MFCD12027255
- Synonyms:2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-4-methyl-2-oxo-;8C;4u8C;4Μ8C;7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde;4-Methyl-7-hydroxy-8-formylcoumarin;7-Hydroxy-8-formyl-4-methylcoumarin;8-Formyl-7-hydroxy-4-methyl-2H-1-benzopyran-2-one
3 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0949
- Product description4μ8C ≥98% (HPLC)
- Packaging25MG
- Price₹46515.03
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number412512
- Product descriptionIRE1 Inhibitor III, 4μ8C - CAS 14003-96-4 - Calbiochem IRE1 Inhibitor III, CAS 14003-96-4, is a cell-permeable. Covalent inhibitor of IRE1 RNase activity (IC?? = 550 and 45 nM, respectively, with 0 & 16 mi
- Packaging25MG
- Price₹12220
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0949
- Product description4μ8C ≥98% (HPLC)
- Packaging5MG
- Price₹11420.38
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | SML0949 | 4μ8C ≥98% (HPLC) | 25MG | ₹46515.03 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 412512 | IRE1 Inhibitor III, 4μ8C - CAS 14003-96-4 - Calbiochem IRE1 Inhibitor III, CAS 14003-96-4, is a cell-permeable. Covalent inhibitor of IRE1 RNase activity (IC?? = 550 and 45 nM, respectively, with 0 & 16 mi | 25MG | ₹12220 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | SML0949 | 4μ8C ≥98% (HPLC) | 5MG | ₹11420.38 | 2022-06-14 | Buy |
Properties
Melting point :189-190℃ (ethanol )
Boiling point :398.3±42.0 °C(Predicted)
Density :1.541
refractive index :1.641
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :6.22±0.20(Predicted)
form :Yellow powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :RTHHSXOVIJWFQP-UHFFFAOYSA-N
CAS DataBase Reference :14003-96-4
Boiling point :398.3±42.0 °C(Predicted)
Density :1.541
refractive index :1.641
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :6.22±0.20(Predicted)
form :Yellow powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :RTHHSXOVIJWFQP-UHFFFAOYSA-N
CAS DataBase Reference :14003-96-4
Safety Information
Symbol(GHS): |
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Description
4μ8C (14003-96-4) is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50?= 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity.1?Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells.2?Blocks production of IL-4, IL-5 and IL-13 production in T cells.3?4μ8C prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells.4More related product prices
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