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ChemicalBook > Product Catalogue >Pharmaceutical intermediates >Bulk Drug Intermediates >7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde

7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde

7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde Structure
  • ₹11420.38 - ₹46515.03
  • Product name: 7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde
  • CAS: 14003-96-4
  • MF: C11H8O4
  • MW: 204.18
  • EINECS:
  • MDL Number:MFCD12027255
  • Synonyms:2H-1-Benzopyran-8-carboxaldehyde, 7-hydroxy-4-methyl-2-oxo-;8C;4u8C;4Μ8C;7-hydroxy-4-Methyl-2-oxo-2H-1-Benzopyran-8-carboxaldehyde;4-Methyl-7-hydroxy-8-formylcoumarin;7-Hydroxy-8-formyl-4-methylcoumarin;8-Formyl-7-hydroxy-4-methyl-2H-1-benzopyran-2-one
3 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0949
  • Product description4μ8C ≥98% (HPLC)
  • Packaging25MG
  • Price₹46515.03
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number412512
  • Product descriptionIRE1 Inhibitor III, 4μ8C - CAS 14003-96-4 - Calbiochem IRE1 Inhibitor III, CAS 14003-96-4, is a cell-permeable. Covalent inhibitor of IRE1 RNase activity (IC?? = 550 and 45 nM, respectively, with 0 & 16 mi
  • Packaging25MG
  • Price₹12220
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0949
  • Product description4μ8C ≥98% (HPLC)
  • Packaging5MG
  • Price₹11420.38
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0949 4μ8C ≥98% (HPLC) 25MG ₹46515.03 2022-06-14 Buy
Sigma-Aldrich(India) 412512 IRE1 Inhibitor III, 4μ8C - CAS 14003-96-4 - Calbiochem IRE1 Inhibitor III, CAS 14003-96-4, is a cell-permeable. Covalent inhibitor of IRE1 RNase activity (IC?? = 550 and 45 nM, respectively, with 0 & 16 mi 25MG ₹12220 2022-06-14 Buy
Sigma-Aldrich(India) SML0949 4μ8C ≥98% (HPLC) 5MG ₹11420.38 2022-06-14 Buy

Properties

Melting point :189-190℃ (ethanol )
Boiling point :398.3±42.0 °C(Predicted)
Density :1.541
refractive index :1.641
storage temp. :-20°C
solubility :DMSO: soluble5mg/mL, clear (warmed)
pka :6.22±0.20(Predicted)
form :Yellow powder
color :white to beige
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :RTHHSXOVIJWFQP-UHFFFAOYSA-N
CAS DataBase Reference :14003-96-4

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H350 May cause cancer Carcinogenicity Category 1A, 1B Danger GHS hazard pictograms
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P271 Use only outdoors or in a well-ventilated area.
P272 Contaminated work clothing should not be allowed out of the workplace.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P285 In case of inadequate ventilation wear respiratory protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.

Description

4μ8C (14003-96-4) is a selective inhibitor of IRE1α ribonuclease (RNase) activity (IC50?= 60 nM). Covalently binds to lysine 907 in the IRE1 endonuclease domain, blocking substrate access to the active site of IRE1α and inactivating both XBP1 splicing and IRE1α-mediated mRNA degradation but not IRE1 kinase activity.1?Inhibits IRE1α in response to hypoxia or other ER stress-inducing agents but has no effect on proliferation or clonogenic survival of hypoxic cells.2?Blocks production of IL-4, IL-5 and IL-13 production in T cells.3?4μ8C prevents the splicing of the XBP1 mRNA in response to ER stress caused by mutant proinsulin production in pancreatic β-cells.4

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