Dabigatran etexilate
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- Product name: Dabigatran etexilate
- CAS: 211915-06-9
- MF: C34H41N7O5
- MW: 627.73
- EINECS:606-722-8
- MDL Number:MFCD22422841
- Synonyms:Pradaxa (dabigatran);Dabigatran Etexilate (free base);Alanine, N-[[2-[[[4-[[[(hexyloxy)carbonyl]aMino]iMinoMethyl]phenyl]aMino]Methyl]-1-Methyl-1H-benziMidazol-5-yl]carbonyl]-N-2-pyridinyl-, ethyl ester;BIBR-1048(Dabigatran etexilate);BIBR 1048;Prazaxa;(E)-ethyl 3-(2-((4-(N'-(hexyloxycarbonyl)carbamimidoyl)phenylamino)methyl)-1-methyl-N-(pyridin-2-yl)-1H-benzo[d]imidazole-5-carboxamido)propanoate;BIBR-1048, >=99%
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Properties
Melting point :128-129°
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :9.88±0.46(Predicted)
form :Solid
color :White to Pale Yellow
Stability :Hygroscopic
Density :1.24±0.1 g/cm3(Predicted)
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO (Slightly), Methanol (Slightly)
pka :9.88±0.46(Predicted)
form :Solid
color :White to Pale Yellow
Stability :Hygroscopic
Safety Information
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Description
Dabigatran etexilate is a double prodrug that undergoes in vivo hydrolytic cleavage to produce dabigatran , a potent thrombin inhibitor (Ki = 4.5 nM). Dabigatran also inhibits trypsin (Ki = 50.3 nM), but only weakly inhibits other serine proteases. The prodrug dabigatran etexilate shows antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action. It is not metabolized by cytochrome P450 isozymes and has a low potential for drug-drug interactions.More related product prices
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