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ML335

ML335 Structure
  • ₹0
  • Product name: ML335
  • CAS: 825658-06-8
  • MF: C15H14Cl2N2O3S
  • MW: 373.25
  • EINECS:
  • MDL Number:MFCD06003481
  • Synonyms:ML335; ML-335; ML 335; TREK-1/2 ACTIVATOR;TREK-1/2 Activator;Benzamide, N-[(2,4-dichlorophenyl)methyl]-4-[(methylsulfonyl)amino]-;Potassium Channel,ML-335,ML 335,ML335,KcsA,Inhibitor,inhibit
Manufacturer Product number Product description Packaging Price Updated Buy

Properties

storage temp. :-20°
solubility :Soluble in DMSO (up to 50 mg/ml) or in Ethanol (up to 20 mg/ml with warming).
form :solid
color :White
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321 Specific treatment (see … on this label).
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P362 Take off contaminated clothing and wash before reuse.

Description

Two-pore domain potassium (K2P) channels of the TREK subfamily regulate neuronal excitability, influence pain, temperature perception and responses to anesthetics. ML-335 (825658-06-8) is a novel, selective TREK-1,2 activator with EC50s of 14.3 and 5.2 μM.1?It represents an important new pharmacological tool for studying the physiology of TREK channels.

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