BAY 87-2243
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- ₹7760 - ₹31350
- Product name: BAY 87-2243
- CAS: 1227158-85-1
- MF: C26H26F3N7O2
- MW: 525.53
- EINECS:
- MDL Number:MFCD28143915
- Synonyms:1-cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]-piperazine;1-cyclopropyl-4-{4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine BAY87-2243;BAY 87-2243;BAY 87-2243 USP/EP/BP;Piperazine, 1-cyclopropyl-4-[4-[[5-methyl-3-[3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl]-1H-pyrazol-1-yl]methyl]-2-pyridinyl]-;BAY87 2243;BAY 87 2243;BAY87-2243;CS-1786;1-cyclopropyl-4-{4-[(5-methyl-3-{3-[4-(trifluoromethoxy)phenyl]-1,2,4-oxadiazol-5-yl}-1H-pyrazol-1-yl)methyl]pyridin-2-yl}piperazine
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML2384
- Product descriptionBAY 87-2243 ≥98% (HPLC)
- Packaging5MG
- Price₹7760
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML2384
- Product descriptionBAY 87-2243 ≥98% (HPLC)
- Packaging25MG
- Price₹31350
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML2384 | BAY 87-2243 ≥98% (HPLC) | 5MG | ₹7760 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML2384 | BAY 87-2243 ≥98% (HPLC) | 25MG | ₹31350 | 2022-06-14 | Buy |
Properties
Boiling point :677.7±65.0 °C(Predicted)
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :RT
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (10 mg/ml).
pka :8.43±0.27(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Density :1.47±0.1 g/cm3(Predicted)
storage temp. :RT
solubility :Soluble in DMSO (up to 25 mg/ml) or in Ethanol (10 mg/ml).
pka :8.43±0.27(Predicted)
form :solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
Safety Information
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Description
BAY 87-2243 (1227158-85-1) potently inhibits HIF-1 reporter gene activity (IC50?= 0.7 nM) and CA9 protein expression (IC50?= 2.0 nM).1?It inhibited HIF-1α and HIF-2α protein accumulation in hypoxic H460 cells and reduced tumor weight in nude mice inoculated with H460 cells. BAY 87-2243 potently inhibits mitochondrial complex I activity (IC50?= 10 nM in mitochondria isolated from PC3 cells) leading to its HIF-1 effects. It has no effect on mitochondrial complex III. BAY 87-2243 reduced melanoma tumor growth?via?its targeting of mitochondrial complex I.2,3Related product price
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