GSK-3β Inhibitor XVIII
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- ₹14260
- Product name: GSK-3β Inhibitor XVIII
- CAS: 1139875-74-3
- MF: C20H20ClN5OS
- MW: 413.92
- EINECS:
- MDL Number:MFCD32671859
- Synonyms:GSK-3β Inhibitor XVIII;GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem;GSK3β-IN-1a;GSK3β Inhibitor XVIII;Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-;GSK3β-IN-1a;2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-,methanone;GSK-3β inhibitor 8
1 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product number361562
- Product descriptionGSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem The GSK-3β Inhibitor XVIII, also referenced under CAS 1139875-74-3, controls the biological activity of GSK-3β. This small molecule/inhibitor is prima
- Packaging5MG
- Price₹14260
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | 361562 | GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem The GSK-3β Inhibitor XVIII, also referenced under CAS 1139875-74-3, controls the biological activity of GSK-3β. This small molecule/inhibitor is prima | 5MG | ₹14260 | 2022-06-14 | Buy |
Properties
Boiling point :632.3±65.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :DMSO: soluble
pka :6?+-.0.10(Predicted)
form :White solid
color :White to off-white
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :DMSO: soluble
pka :6?+-.0.10(Predicted)
form :White solid
color :White to off-white
Safety Information
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Description
GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.More related product prices
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