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GSK-3β Inhibitor XVIII

GSK-3β Inhibitor XVIII Structure
  • ₹14260
  • Product name: GSK-3β Inhibitor XVIII
  • CAS: 1139875-74-3
  • MF: C20H20ClN5OS
  • MW: 413.92
  • EINECS:
  • MDL Number:MFCD32671859
  • Synonyms:GSK-3β Inhibitor XVIII;GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem;GSK3β-IN-1a;GSK3β Inhibitor XVIII;Methanone, [2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-;GSK3β-IN-1a;2-chloro-4-[[4-(2-thienyl)-2-pyrimidinyl]amino]phenyl](4-methyl-1-piperazinyl)-,methanone;GSK-3β inhibitor 8
Price1 Properties Safety Information Description
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Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product number361562
  • Product descriptionGSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem The GSK-3β Inhibitor XVIII, also referenced under CAS 1139875-74-3, controls the biological activity of GSK-3β. This small molecule/inhibitor is prima
  • Packaging5MG
  • Price₹14260
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) 361562 GSK-3β Inhibitor XVIII - CAS 1139875-74-3 - Calbiochem The GSK-3β Inhibitor XVIII, also referenced under CAS 1139875-74-3, controls the biological activity of GSK-3β. This small molecule/inhibitor is prima 5MG ₹14260 2022-06-14 Buy

Properties

Boiling point :632.3±65.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :+2C to +8C
solubility :DMSO: soluble
pka :6?+-.0.10(Predicted)
form :White solid
color :White to off-white

Safety Information

Symbol(GHS):
Signal word:
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
Precautionary statements:

Description

GSK3β inhibitor XVIII is an inhibitor of glycogen synthase kinase 3β (GSK3β; IC50 = 64 nM). It induces expression of a luciferase reporter in HEK293 cells expressing wild-type Wnt (EC50 = ~1.25 μM) but not in cells expressing a β-catenin/TCF binding site-mutant Wnt. GSK3β inhibitor XVIII increases β-catenin accumulation in the nucleus of HEK293 cells. It induces proliferation of R7T1 β-cells (EC50 = 1,143 nM), an effect that can be blocked by the COX and Wnt signaling inhibitor sulindac , and rat primary β-cells.

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Suppliers and manufacturers

Riedel-de Haen AG Shanghai Hao Biological Technology Co., Ltd. Morning Student Science and Technology (Guangzhou) Co., Ltd. Absin Bioscience Inc. Boao Pike Shanghai Hao Zhun Biological Technology Co., Ltd. ChemeGen(Shanghai) Biotechnology Co.,Ltd. Cayman Chemical Company Shanghai EFE Biological Technology Co., Ltd. TargetMol Chemicals Inc.