Boiling point :532.3±50.0 °C(Predicted) Density :1.175 storage temp. :-20°C Freezer pka :4.77±0.10(Predicted)
Safety Information
Symbol(GHS):
Signal word:
Warning
Hazard statements:
Code
Hazard statements
Hazard class
Category
Signal word
Pictogram
P-Codes
H302
Harmful if swallowed
Acute toxicity,oral
Category 4
Warning
P264, P270, P301+P312, P330, P501
H315
Causes skin irritation
Skin corrosion/irritation
Category 2
Warning
P264, P280, P302+P352, P321,P332+P313, P362
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Category 2A
Warning
P264, P280, P305+P351+P338,P337+P313P
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure;Respiratory tract irritation
Category 3
Warning
Precautionary statements:
P261
Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312
IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352
IF ON SKIN: wash with plenty of soap and water.
P304+P340
IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
Description
Chronic constipation is an affliction affecting 4–5 million Americans alone.
When no specific cause is identified, it is classified as idiopathic. Dietary and
lifestyle modifications are the first-line conventional approaches followed by the
administration of laxatives. Unfortunately, chronic idiopathic constipation is frequently
refractory to traditional therapy; thus, the need for novel agents exists.
Lubiprostone is a bicyclic fatty acid with a novel mechanism of action. Without
affecting sodium and potassium ion concentrations, lubiprostone activates
intestinal chloride ion channels, thereby, increasing intestinal water secretion
and intestinal fluid chloride ion concentration. In basolateral membranepermeabilized
T84 gastrointestinal epithelial cells under chloride gradient conditions,
lubiprostone concentration-dependently increased short-circuit current
with an EC50 of approximately 20 nM.
