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Ondansetron

Ondansetron Structure
CAS No.
99614-02-5
Chemical Name:
Ondansetron
Synonyms
ONDANSETRON HCL;ONDANSETRON HYDROCHLORIDE DIHYDRATE;ONDANSETRON HCL DIHYDRATE;Ondanestron;Yatrox;gr38032;gr38032x;Ondanles;GR 38032F;HSDB 6544
CBNumber:
CB6340203
Molecular Formula:
C18H19N3O
Molecular Weight:
293.36
MOL File:
99614-02-5.mol
Modify Date:
2023/6/8 9:02:50
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Ondansetron Properties

Melting point 231-232°
Boiling point 435.21°C (rough estimate)
Density 1.1385 (rough estimate)
refractive index 1.5855 (estimate)
storage temp. −20°C
solubility H2O: >5 mg/mL
form solid
pka pKa 7.4 (Uncertain)
color white
CAS DataBase Reference 99614-02-5(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS) 
GHS05,GHS06,GHS09
Signal word  Danger
Hazard statements  H301-H318-H410
Precautionary statements  P264-P273-P280-P301+P310+P330-P305+P351+P338+P310-P391
Hazard Codes  T,Xi
Risk Statements  25-36/37/38
Safety Statements  45-37/39-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS  FE6375500
HS Code  29339900
Toxicity TDLo vn-man: 229 mg/kg/I LANCAO 344,190,94
NFPA 704
3
0 0

Ondansetron Chemical Properties,Uses,Production

Description

Ondansetron (hydrochloride) (CRM) (Item No. 21710) is a certified reference material categorized as an antiemetic. Formulations containing ondansetron have been used to reduce alcohol consumption and mood disturbances in early-onset alcoholics. This product is intended for research and forensic applications.

Chemical Properties

White to yellow crystal

Uses

antibacterial

Indications

Ondansetron (Zofran) is potent antagonists of 5-HT3 receptors,which is found peripherally on vagal nerve terminals and centrally in the CTZ. During chemotherapy that induces vomiting, mucosal enterochromaffin cells in the GI tract release serotonin, which stimulates 5-HT3 receptors.

Side effects

This causes vagal afferent discharge, inducing vomiting. In binding to 5-HT3 receptors, ondansetron blocks serotonin stimulation, hence vomiting, after emetogenic stimuli such as cisplatin. Headache is the most frequently reported adverse effect of these medications.

Safety Profile

A poison by intravenous route.Human systemic effects by intravenous route: jaundice.When heated to decomposition it emits toxic vapors ofNOx.

Ondansetron Preparation Products And Raw materials

Raw materials

Lithium tert-butoxide Ondansetron hydrochloride dihydrate 2-Bromoaniline Paraformaldehyde Dimethylamine hydrochloride
2-Methylimidazole 1,3-Cyclohexanedione Cyclohexanone Dimethylamine Iodomethane
1,4-Benzoquinone 1,2,3,4-Tetrahydrocarbazole Sodium Diethyl oxalate
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Preparation Products

Ondansetron Suppliers

Global( 306)Suppliers
Supplier Tel Country ProdList Advantage Inquiry
Ipca Laboratories Ltd +91-2262105000 +91-2262105000 Maharashtra, India 61 58 Inquiry
Hikal Ltd. +91-9538444622 +91-8067356100 Maharashtra, India 31 58 Inquiry
Sun Pharmaceutical Industries Ltd +91-2242244224 +91-2243244324 Maharashtra, India 108 58 Inquiry
Anugraha Chemicals +91-8041685494 +91-9845939733 Karnataka, India 22 58 Inquiry
Dayaram Pharma Chem +91-9601766800 +91-9601766800 Gujarat, India 61 58 Inquiry
Synergene Active Ingredients Pvt. Ltd. +91-04023700774 +91-04023700774 Telangana, India 96 58 Inquiry
Chempifine Chemicals +91-2225667766 +91-2225667766 Punjab, India 144 58 Inquiry
Rivashaa Agrotech Biopharma Pvt. Ltd. +91-26463395 +91-7926462688 Gujarat, India 1615 58 Inquiry
Besil Chem LLP +91-7760252666 +91-9880731835 Bangalore, India 163 58 Inquiry
Yogi Enterprise +91-9377714435 +91-9824314435 Gujarat, India 91 58 Inquiry
Supplier Advantage
Ipca Laboratories Ltd 58
Hikal Ltd. 58
Sun Pharmaceutical Industries Ltd 58
Anugraha Chemicals 58
Dayaram Pharma Chem 58
Synergene Active Ingredients Pvt. Ltd. 58
Chempifine Chemicals 58
Rivashaa Agrotech Biopharma Pvt. Ltd. 58
Besil Chem LLP 58
Yogi Enterprise 58

Ondansetron Spectrum

Ondansetron(99614-02-5)1HNMR

99614-02-5(Ondansetron)Related Search:

1-Methylimidazole POLY(N-VINYLCARBAZOLE) Paraquat dichloride Acetonitrile Basic Violet 1
Methyl acrylate Palonosetron Palonosetron Hydrochloride Ondansetron dihydrate hydrochloride,Ondansetron hydrochloride,ONDANSETRON HYDROCHLORIDE HYDRATE Granisetron hydrochloride
Granisetron Methyl acetate Kresoxim-methyl Methanol Methylparaben
Methyl ONDANSETRON FOR LC SYSTEM SUITABILITY 1,2,3,9-TETRAHYDRO-4H-CARBAZOLE-4-ONE(CARVEDILOL ,ONDANSETRON INTERMEDIATE )
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1,2,3,9-tetrahydro-9-methyl-3-((2-methyl-1h-imidazol-1-yl)methyl)-4h-carbazo gr38032 gr38032x GR 38032F 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]- (9CI) Ondansetron ONDANSETRONE HYDROCHLORIDE 1,2,3,4-TETRAHYDRO-9-METHYL-3-(2-METHYL-1H-IMIDAZOLE-1-YLMETHYL)CARBAZOL-4-ONE 9-Methyl-3-[(2-methyl-1H-imidazolyl)-methyl]-1,2,3,9-tetrahydro-4H-carbazole-4-one OndansetronBase99% 1,2,3,4-Tetrahydro-9-methyl-3-(2-methyl-1H-imidazol-1-ylmethyl)carbazol-4-one 1,2,3,4-Tetrahydro-9-methyl-3-(2-methyl-1H-imidazol-1-ylmethyl)carbazole-4-one 1，2，3，9-Tetrahydm-9-methyl-3-[(2-methyl-1H-imidazol-1-y1)methyl]-4H-carbazol-4-one GR-C507/75 1,2,3,4-Tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-9H-carbazol-4-one 1,2-Dihydro-9-methyl-3-(2-methyl-1H-imidazol-1-ylmethyl)-9H-carbazol-4(3H)-one 9-Methyl-3-[(2-methyl-1H-imidazole-1-yl)methyl]-1,2,3,4-tetrahydro-9H-carbazole-4-one Ondansetron (300 mg)F0E2810.999mg/mg(an) Ondansetron (300 mg) 9-Methyl-3-[(2-Methyl-1H-iMidazol-1-yl)Methyl]-2,3,4,9-tetrahydro-1H-carbazol-4-one Ondansetron (Zofran) Ondanles Yatrox (RS)-1,2,3,9-Tetrahydro-9-methyl-3-(2-methylimidazol-1-ylmethyl)carbazol-4-one Ondansetron, >=99% 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one hydrate hydrochloride (RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4(9H)-one Ondansetro ondanserton Ondansetron, 98%, a serotonin 5-HT3 receptor antagonist Ondansetron (hydrochloride) (CRM) Ondansetron for LC system suitability CRS Ondansetron for TLC system suitability CRS 4H-Carbazol-4-one, 1,2,3,9-tetrahydro-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]- ONDANCETRON Ondansetron USP/EP/BP Ondansetron (GR 38032 Antiemetic Ondansetron Ondansetron (1478571) HSDB 6544 ONDANSETRON HCL ONDANSETRON HCL DIHYDRATE ONDANSETRON HYDROCHLORIDE DIHYDRATE Ondanestron 6,6’-Methylenebis[(3RS)-9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one-d6 (Ondansetron Impurity B) 13C]-Ondansetron 99614-02-5 103639-04 C18H19N3OHCl2H2O C18H19N3OHCl C18H19N3O Ondansetron Active Pharmaceutical Ingredients Inhibitors DYNABAC Serotonin