ChemicalBook > Product Catalog >API >Circulatory system drugs >Angina Pectoris Drugs >Naftopidil dihydrochloride
Naftopidil dihydrochloride
- CAS No.
- 57149-07-2
- Chemical Name:
- Naftopidil dihydrochloride
- Synonyms
- kt-611;Flivas;Avishot;Naftopil;BM-15275;Naftopiil;NafTopIDi1;NAFTOPIDIL;Nafitopidil;Naftopidil>
- CBNumber:
- CB6356910
- Molecular Formula:
- C24H28N2O3
- Molecular Weight:
- 392.49
- MOL File:
- 57149-07-2.mol
- Modify Date:
- 2023/5/18 11:31:00
| Melting point | 127 °C |
|---|---|
| Boiling point | 517.2°C (rough estimate) |
| Density | 1.1592 (rough estimate) |
| refractive index | 1.6300 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | methanol: >10 mg/mL |
| form | solid |
| pka | 14.01±0.20(Predicted) |
| color | white |
| Merck | 14,6356 |
| CAS DataBase Reference | 57149-07-2(CAS DataBase Reference) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Warning |
| Hazard statements | H361 |
| Precautionary statements | P201-P202-P281-P308+P313-P405-P501 |
| RIDADR | 3077 |
| WGK Germany | 3 |
| RTECS | TL9336500 |
| HS Code | 29335990 |
| Toxicity | LD50 in mice, rats (g/kg): 1.3, 6.4 orally (Himmel) |
Naftopidil dihydrochloride price More Price(3)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | N158 | Naftopidil hydrochloride hydrate solid | 57149-07-2 | 25MG | ₹19290.15 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | N158 | Naftopidil hydrochloride hydrate solid | 57149-07-2 | 100MG | ₹74865.7 | 2022-06-14 | Buy |
| TCI Chemicals (India) | N0832 | Naftopidil | 57149-07-2 | 5G | ₹8700 | 2022-05-26 | Buy |
Naftopidil dihydrochloride Chemical Properties,Uses,Production
Description
Naftopidil was launched in Japan for the treatment of dysuria associated with benign prostatic hypertrophy (BPH). It can be prepared by a two step route starting with α-naphthol. Naftopidil is a potent postsynaptic-selective alpha-l-antagonist with a slightly higher affinity for the human prostatic than for the aortic alpha-adrenoceptor. It also shows a 5-HT1A agonistic effect, as well as a weak calcium antagonistic activity, but no alpha-2 or beta-adrenoreceptor affinity. In experiments with rats or rabbits, Naftopidil was shown to be more potent and selective for the urodynamic effect than the hypotensive effect. Aromatic or aliphatic hydroxylation are the major routes of metabolism, producing metabolites with a profile similar to the parent compound.
Chemical Properties
Off-White Solid
Uses
A α-1-Adrenergic receptor antagonist, antihypertensive.
Biological Activity
An α 1 -adrenoceptor antagonist with only weak antagonism at post-junctional α 2 receptors; a potent, persistent antihypertensive and vasodilator.
Naftopidil dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 352)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| Hetero Drugs Limited | +91-4023704923 +91-4023704923 | Telangana, India | 296 | 58 | Inquiry |
| Trimax bio sciences private ltd | +91-8532299988 +91-8532299988 | Karnataka, India | 36 | 58 | Inquiry |
| Hetero Drugs Limited | 08048372500Ext 439 | Hyderabad, India | 174 | 58 | Inquiry |
| Lewens Labs | 91-7043057100 | Gujarat, India | 5 | 58 | Inquiry |
| Chempro Pharma Pvt. Ltd. | 91-22-40945230 | Maharashtra, India | 170 | 58 | Inquiry |
| Clearsynth Labs | 91-22-45045900 | Maharashtra, India | 3889 | 58 | Inquiry |
| Oceanic Pharmachem Pvt., Ltd. (OPPL) | 91-22-42128600 | Maharashtra, India | 947 | 58 | Inquiry |
| KPS Chemicals & Pharmaceuticals | 91--8469484608 | Gujarat, India | 240 | 58 | Inquiry |
| Sachem | 91-9810014878 | Delhi, India | 75 | 58 | Inquiry |
| Vyshno Bio Sciences | 91-7095439993 | Hyderabad, India | 239 | 58 | Inquiry |
| Supplier | Advantage |
|---|---|
| Hetero Drugs Limited | 58 |
| Trimax bio sciences private ltd | 58 |
| Hetero Drugs Limited | 58 |
| Lewens Labs | 58 |
| Chempro Pharma Pvt. Ltd. | 58 |
| Clearsynth Labs | 58 |
| Oceanic Pharmachem Pvt., Ltd. (OPPL) | 58 |
| KPS Chemicals & Pharmaceuticals | 58 |
| Sachem | 58 |
| Vyshno Bio Sciences | 58 |
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57149-07-2
7149-07-2
C24H28N2O3
C24H30Cl2N2O3
C24H28N2O3HCl
AVISHOT