PURVALANOL A
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- ₹11880.01 - ₹14462.2
- Product name: PURVALANOL A
- CAS: 212844-53-6
- MF: C19H25ClN6O
- MW: 388.89
- EINECS:
- MDL Number:MFCD02179211
- Synonyms:PURVALANOL A;NG-60;6-(3-CHLOROANILINO)-2(1R)-ISOPROPYL-2-HYDROXYETHYLAMINO-9-ISOPROPYLPURINE;(2R)-2-[[6-[(3-CHLOROPHENYL)AMINO]-9-(1-METHYLETHYL)-9H-PURIN-2-YL]AMINO]-3-METHYL-1-BUTANOL;2-(1R-ISOPROPOYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE;2-(1R-ISOPROPYL-2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYL-PURINE;CH61386;2R)-2-[[6-[(3-Chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]-3-methyl-1-butanolCDKinhibitor.
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- ManufacturerSigma-Aldrich(India)
- Product number540500
- Product descriptionPurvalanol A - CAS 212844-53-6 - Calbiochem A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases.
- Packaging1MG
- Price₹11880.01
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberP4484
- Product descriptionPurvalanol A ≥98% (HPLC), powder
- Packaging1MG
- Price₹14462.2
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 540500 | Purvalanol A - CAS 212844-53-6 - Calbiochem A potent, cell-permeable, reversible, and selective inhibitor of cyclin-dependent kinases. | 1MG | ₹11880.01 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | P4484 | Purvalanol A ≥98% (HPLC), powder | 1MG | ₹14462.2 | 2022-06-14 | Buy |
Properties
Boiling point :590.5±60.0 °C(Predicted)
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :methylene chloride: 50 mg/mL, clear, colorless
form :powder
pka :14.51±0.10(Predicted)
color :off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Density :1.33±0.1 g/cm3(Predicted)
storage temp. :Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
solubility :methylene chloride: 50 mg/mL, clear, colorless
form :powder
pka :14.51±0.10(Predicted)
color :off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months.
Safety Information
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Description
Purvalanol A is a potent, cell-permeable, and selective inhibitor of cyclin-dependent kinases (CDKs) with IC50 values of 4, 70, 35, 850, and 75 nM for cdc2/cyclin B, Cdk2/cyclin A, Cdk2/cyclin E, Cdk4/cyclin D1 and Cdk5-p35, respectively. Purvalanol A reversibly arrests synchronized cells in the G1 and G2 phase of the cell cycle, inhibiting both cell proliferation and cell death. At 10 μM, purvalanol A potently suppresses the anchorage-independent growth of c-Src-transformed cells as well as HT-29 and SW48 human colon cancer cells.More related product prices
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