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ChemicalBook > Product Catalogue >API >Antineoplastic agents >Regorafenib

Regorafenib

Regorafenib Structure
  • ₹6800 - ₹14800
  • Product name: Regorafenib
  • CAS: 755037-03-7
  • MF: C21H15ClF4N4O3
  • MW: 482.82
  • EINECS:815-051-1
  • MDL Number:MFCD16038047
  • Synonyms:4-[4-({[4-chioro-3-(trifluoroMethyl)phenyl]carbaMoyl}aMino)-3-fluorophenoxy]-pyridine-2-carboxylic acid MethylaMide;REGORAFENIB BAY 73-4506 BAYER HEALTHCARE (SEE ALSO COLORECTAL, LUNG, STOMACH) PHASE II(REGORAFENIB) PHARMACEUTICALS (888) 842-2937WAYNE, NJ;4-[4-[[[[4-Chloro-3-(trifluoroMethyl)phenyl]aMino]carbonyl]aMino]-3-fluorophenoxy]-N-Methyl-2-pyridinecarboxaMide;4-[4-[N'-(4-Chloro-3-trifluoroMethylphenyl)ureido]-3- fluorophenoxy]pyridine-2-carboxylic Acid MethylaMide;regorafinib;Regafenib;Reggae sorafenib;Regorafenib C3X-1410
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • TCI Chemicals (India)

Package

  • 25MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberR0142
  • Product descriptionRegorafenib
  • Packaging25MG
  • Price₹6800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberR0142
  • Product descriptionRegorafenib
  • Packaging100MG
  • Price₹14800
  • Updated2022-05-26
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) R0142 Regorafenib 25MG ₹6800 2022-05-26 Buy
TCI Chemicals (India) R0142 Regorafenib 100MG ₹14800 2022-05-26 Buy

Properties

Melting point :206.0 to 210.0 °C
Boiling point :513.4±50.0 °C(Predicted)
Density :1.491±0.06 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :DMSO (Slightly), Methanol (Slightly)
pka :12.04±0.70(Predicted)
form :White powder.
color :Pale Pink to Light Pink
CAS DataBase Reference :755037-03-7

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Regorafenib is an orally-bioavailable multi-kinase inhibitor that is structurally related to sorafenib (BAY 43-9006; ), another multi-kinase inhibitor with applications in cancer. Regorafenib inhibits c-Raf, B-Raf, VEGFR1, VEGFR2, VEGFR3, Tie2, PDGFRβ, FGFR1, c-Kit, and RET with IC50 values of 2.5, 28, 13, 4.2, 46, 311, 22, 202, 7, and 1.5 nM, respectively, as well as other kinases. It also inhibits soluble epoxide hydrolase (IC50 = 0.5 nM). Regorafenib has value against a range of cancers, including advanced colorectal cancer.

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Suppliers and manufacturers

GLR Innovations Prajna generics pvt ltd NATCO Pharma Limited Aspen Biopharma Labs Pvt Ltd Archerchem Healthcare Pvt., Ltd. (part of Archerchem Group) Yasham Speciality ingredients Pvt Ltd Avra Laboratories Pvt., Ltd. Pharma Affiliates Prajna Generics Private Limited NATCO PHARMA LIMITED