Name: TYRPHOSTIN AG 879
Brand: chemicalbook
SKU: 148741-30-4

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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >protein tyrosine kinase >TYRPHOSTIN AG 879

TYRPHOSTIN AG 879

₹14169.93
Product name: TYRPHOSTIN AG 879
CAS: 148741-30-4
MF: C18H24N2OS
MW: 316.46
EINECS:
MDL Number:MFCD00236450
Synonyms:2-Propenethioamide, 3-[3,5-bis(1,1-dimethylethyl)-4-hydroxyphenyl]-2-cyano-, (E)-;AG-879 100MG;TYRPHOSTIN 879;TYRPHOSTIN AG 879;(3,5-DI-T-BUTYL-4-HYDROXYBENZYLIDENE)THIOCYANOACETAMIDE;AG 879;ALPHA-CYANO-(3,5-DI-T-BUTYL-4-HYDROXY)THIOCINNAMIDE;ALPHA-CYANO-(3,5-DI-TERT-BUTYL-4-HYDROXY)THIOCINNAMAMIDE

Price1 Properties Safety Information Description

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Selected condition：

Brand

Sigma-Aldrich(India)

Package

ManufacturerSigma-Aldrich(India)
Product numberT2067
Product descriptionTyrphostin AG 879 99% (HPLC)
Packaging5MG
Price₹14169.93
Updated2022-06-14
Buy

Manufacturer	Product number	Product description	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	T2067	Tyrphostin AG 879 99% (HPLC)	5MG	₹14169.93	2022-06-14	Buy

Properties

Boiling point :432.7±55.0 °C(Predicted)
Density :1.127±0.06 g/cm3(Predicted)
storage temp. :Keep in dark place,Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: at 26 mg/mlsoluble
pka :9.63±0.70(Predicted)
form :Orange-yellow solid
color :Yellow
Stability :Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS):

Signal word:

Warning

Hazard statements:

Code	Hazard statements	Hazard class	Category	Signal word	P-Codes
H302	Harmful if swallowed	Acute toxicity,oral	Category 4	Warning	P264, P270, P301+P312, P330, P501
H312	Harmful in contact with skin	Acute toxicity,dermal	Category 4	Warning	P280,P302+P352, P312, P322, P363,P501
H315	Causes skin irritation	Skin corrosion/irritation	Category 2	Warning	P264, P280, P302+P352, P321,P332+P313, P362
H319	Causes serious eye irritation	Serious eye damage/eye irritation	Category 2A	Warning	P264, P280, P305+P351+P338,P337+P313P
H332	Harmful if inhaled	Acute toxicity,inhalation	Category 4	Warning	P261, P271, P304+P340, P312

Precautionary statements:

P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P264	Wash hands thoroughly after handling.
P264	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352	IF ON SKIN: wash with plenty of soap and water.
P304+P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P321	Specific treatment (see … on this label).
P322	Specific measures (see …on this label).
P330	Rinse mouth.
P332+P313	IF SKIN irritation occurs: Get medical advice/attention.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P501	Dispose of contents/container to..…

Description

Protein tyrosine kinase (PTK) inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of PTKs. Tyrphostins are a class of antiproliferative compounds which selectively inhibit PTKs of key growth factors. AG-879 is a tyrphostin compound that inhibits nerve growth factor (NGF)-dependent TrkA tyrosine phosphorylation in PC-12 cells (IC50 = ~40 μM), HER2-ErbB2 kinase in several breast and ovarian cancer cell lines (IC50 = ~0.5 μM), and the VEGF receptor FLK1 (IC50 = ~1 μM). Additionally, AG-879 inhibits the activation of ETK with an IC50 value of ~5 nM, which blocks tyrosine phosphorylation of PAK1, suppressing Ras transformation of NIH 3T3 fibroblasts. AG-879 has also been shown to suppress IL-6-induced tyrosine phosphorylation of STAT3 (IC50 = 15 μM) in schwannoma cells.

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Suppliers and manufacturers

TargetMol Chemicals Inc.

₹43.00 /5mg
Tyrphostin AG 879 CAS:148741-30-4

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