WITHAFERIN A
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- ₹18400 - ₹62081.38
- Product name: WITHAFERIN A
- CAS: 5119-48-2
- MF: C28H38O6
- MW: 470.6
- EINECS:999-999-2
- MDL Number:MFCD10687098
- Synonyms:WITHAFERIN A;5,6-beta-epoxy-4-beta,22,27-trihydroxy-1-5-beta-ergosta-24-dien-26-oicacid ;delta-lactone,(20s,22r)-oxo ;nsc-101088 ;(4β,5β,6β,22R)-5,6-Epoxy-4,22,27-trihydroxy-1-oxoergosta-2,24-dien-26-oicacidδ-lactone;NSC 273757;Withaferine;(20S,22R)-5,6β-Epoxy-4β,22,27-trihydroxy-1-oxo-5β-ergosta- 2,24-dien-26-oic Acid δ-Lactone
4 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- 10MG
- ManufacturerSigma-Aldrich(India)
- Product number681535
- Product descriptionWithaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
- Packaging1MG
- Price₹18400
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number681535
- Product descriptionWithaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties.
- Packaging5MG
- Price₹47800
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberW4394
- Product descriptionWithaferin A ≥95% (HPLC)
- Packaging5MG
- Price₹52533.73
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number89910
- Product descriptionWithaferin A analytical standard
- Packaging10MG
- Price₹62081.38
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | 681535 | Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. | 1MG | ₹18400 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 681535 | Withaferin A, Withania somnifera - CAS 5119-48-2 - Calbiochem A cell-permeable steroidal lactone that displays antitumor, anti-inflammatory, radiosensitizing, and immunosuppressive properties. | 5MG | ₹47800 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | W4394 | Withaferin A ≥95% (HPLC) | 5MG | ₹52533.73 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | 89910 | Withaferin A analytical standard | 10MG | ₹62081.38 | 2022-06-14 | Buy |
Properties
Melting point :252-253℃
alpha :D28 +125° (c = 1.30 in CHCl3)
Boiling point :680.7±55.0 °C(Predicted)
Density :1.28
Flash point :226℃
storage temp. :Desiccate at -20°C
solubility :Soluble in DMSO (up to 20 mg/ml)
pka :13.49±0.70(Predicted)
form :White solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :DBRXOUCRJQVYJQ-CKNDUULBSA-N
alpha :D28 +125° (c = 1.30 in CHCl3)
Boiling point :680.7±55.0 °C(Predicted)
Density :1.28
Flash point :226℃
storage temp. :Desiccate at -20°C
solubility :Soluble in DMSO (up to 20 mg/ml)
pka :13.49±0.70(Predicted)
form :White solid
color :White
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :DBRXOUCRJQVYJQ-CKNDUULBSA-N
Safety Information
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Description
Up-regulation of vimentin expression is one of the hallmarks of the epithelial-mesenchymal transition that accompanies the transformation of pre-metastatic to metastatic cancer cells. Withaferin A is a steroidal lactone present in W. somnifera that at 2-25 μM has been shown to bind to and induce aggregation of vimentin intermediate filaments in cultured endothelial cells and fibroblasts, causing apoptosis. As such, it has been proposed as an anti-tumor agent to target metastatic cells that up-regulate vimentin expression. At 2 mg/kg, withaferin A exhibits potent inhibition of angiogenesis in a mouse model of injury-induced corneal neovascularization. Withaferin A can also induce perinuclear aggregates in other intermediate filament networks including peripherin, neurofilament-triplet protein, and keratin as well as disrupt the organization of microtubules and actin/microfilaments.Related product price
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