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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >Apoptosis >Caspase activator >PAC1

PAC1

PAC1 Structure
  • ₹11052.33 - ₹47796.6
  • Product name: PAC1
  • CAS: 315183-21-2
  • MF: C23H28N4O2
  • MW: 392.49
  • EINECS:
  • MDL Number:MFCD03302441
  • Synonyms:PAC1;4-(Phenylmethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]methylene]hydrazide;PAC1,4-(PhenylMethyl)-1-piperazineaceticacid[[2-hydroxy-3-(2-propenyl)phenyl]Methylene]hydrazide;4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide;PAC-1,PAC1;Procaspase activating coMpound 1;(E)-N'-(3-allyl-2-hydroxybenzylidene)-2-(4-benzylpiperazin-1-yl)acetohydrazide;4-(Phenylmethyl)-1-piperazineacetic acid 2-[[2-hydroxy-3-(2-propen-1-yl)phenyl]methylene]hydrazide PAC-1
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 400μL
  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberP0115
  • Product descriptionPAC-1 ≥98% (HPLC)
  • Packaging5MG
  • Price₹11052.33
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberP0115
  • Product descriptionPAC-1 ≥98% (HPLC)
  • Packaging25MG
  • Price₹36761.7
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSAB1301755
  • Product descriptionANTI-DUSP2 (C-TERM) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution
  • Packaging400μL
  • Price₹47796.6
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) P0115 PAC-1 ≥98% (HPLC) 5MG ₹11052.33 2022-06-14 Buy
Sigma-Aldrich(India) P0115 PAC-1 ≥98% (HPLC) 25MG ₹36761.7 2022-06-14 Buy
Sigma-Aldrich(India) SAB1301755 ANTI-DUSP2 (C-TERM) antibody produced in rabbit IgG fraction of antiserum, buffered aqueous solution 400μL ₹47796.6 2022-06-14 Buy

Properties

Density :1.14
storage temp. :Store at +4°C
solubility :DMSO: ≥10mg/mL
form :solid
pka :8.82±0.40(Predicted)
color :white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol must be stored under inert gas at -80°C and will be stable for up to 2 months.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P273 Avoid release to the environment.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PAC 1 is a procaspase-activating compound, which in turn produces caspase-3 (EC50 = 0.22 μM). PAC 1 also activates procaspase-7 in a less efficient manner (EC50 = 4.5 μM). This compound is a proapoptotic, inducing apoptosis in both cancerous and non-cancerous cell lines. The induction of apoptosis is dependent on the concentration of procaspase-3 (IC50 values anre 0.003-1.41 and 5.02=9.98 μM, respectively).

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