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SU5402

SU5402 Structure
  • ₹12297.2 - ₹80730
  • Product name: SU5402
  • CAS: 215543-92-3
  • MF: C17H16N2O3
  • MW: 296.32
  • EINECS:
  • MDL Number:MFCD08235144
  • Synonyms:SU5402;3-[4-METHYL-2-[(2-OXO-1H-INDOL-3-YLIDENE)METHYL]-1H-PYRROL-3-YL]PROPANOIC ACID;3-[3-(2-CARBOXYETHYL)-4-METHYLPYRROL-2-METHYLIDENYL]-2-INDOLINONE;2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)Methyl]-4-Methyl-;SU-5402/SU5402;2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic acid 3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone;3-[4-Methyl-2-(2-oxo-1,2-dihydro-indol-3-ylidenemethyl)-1H-pyrrol-3-yl]-propionic acid;PF-02969207
5 prices
Selected condition:

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 2MG
  • 5MG
  • 25MG
  • 500μG
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0443
  • Product descriptionSU-5402 ≥98% (HPLC)
  • Packaging5MG
  • Price₹12297.2
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number572630
  • Product descriptionSU5402 - CAS 215543-92-3 - Calbiochem SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC?? = 10-20 μM in t
  • Packaging500μG
  • Price₹28660
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberSML0443
  • Product descriptionSU-5402 ≥98% (HPLC)
  • Packaging25MG
  • Price₹50076.45
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number572630
  • Product descriptionSU5402 - CAS 215543-92-3 - Calbiochem SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC?? = 10-20 μM in t
  • Packaging1MG
  • Price₹53810.01
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number572630
  • Product descriptionSU5402 - CAS 215543-92-3 - Calbiochem SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC?? = 10-20 μM in t
  • Packaging2MG
  • Price₹80730
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) SML0443 SU-5402 ≥98% (HPLC) 5MG ₹12297.2 2022-06-14 Buy
Sigma-Aldrich(India) 572630 SU5402 - CAS 215543-92-3 - Calbiochem SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC?? = 10-20 μM in t 500μG ₹28660 2022-06-14 Buy
Sigma-Aldrich(India) SML0443 SU-5402 ≥98% (HPLC) 25MG ₹50076.45 2022-06-14 Buy
Sigma-Aldrich(India) 572630 SU5402 - CAS 215543-92-3 - Calbiochem SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC?? = 10-20 μM in t 1MG ₹53810.01 2022-06-14 Buy
Sigma-Aldrich(India) 572630 SU5402 - CAS 215543-92-3 - Calbiochem SU5402, CAS 215543-92-3, is a cell-permeable, reversible, and ATP-competitive inhibitor of the tyrosine kinase activity of FGFR1 (IC?? = 10-20 μM in t 2MG ₹80730 2022-06-14 Buy

Properties

Melting point :>222°C (dec.)
Boiling point :592.6±50.0 °C(Predicted)
Density :1.363±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :DMSO: soluble10mg/mL (clear solution)
pka :4.60±0.10(Predicted)
form :powder
color :light orange to dark orange
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
InChIKey :JNDVEAXZWJIOKB-JYRVWZFOSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312 IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SU 5402 is a fibroblast growth factor receptor (FGFR)-specific tyrosine kinase inhibitor. Multiple myeloma studies suggest that SU 5402 inhibits FGFR3 phosphorylation in vitro. Research shows that inhibition of FGFR results in the blocking of nodal vesicular parcels (NVPs) secretion and an increase of Ca2+. Additionally, SU 5402 has been observed to inhibit IL-1β-induced MAPK activity.

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