CUDC-101
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- ₹19095.3 - ₹71445
- Product name: CUDC-101
- CAS: 1012054-59-9
- MF: C24H26N4O4
- MW: 434.49
- EINECS:-0
- MDL Number:MFCD15528940
- Synonyms:CUDC101;CUDC-101;7-[[4-(3-Ethynylphenylamino)-7-methoxyquinazolin-6-yl]oxy]-N-hydroxyheptanamide;CUDC101; CUDC 101; CUDC-101.;CS-330;CUDC101;CUDC 101;HeptanaMide, 7-[[4-[(3-ethynylphenyl)aMino]-7-Methoxy-6-quinazolinyl]oxy]-N-hydroxy-;7-[[4-[(3-Ethynylphenyl)aMino]-7-Methoxy-6-quinazolinyl]oxy]-N-hydroxyheptanaMide
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberEPS003
- Product descriptionCUDC 101 A potent inhibitor of HDACs and receptor tyrosine kinases
- Packaging5MG
- Price₹19095.3
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberEPS003
- Product descriptionCUDC 101 A potent inhibitor of HDACs and receptor tyrosine kinases
- Packaging25MG
- Price₹71445
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | EPS003 | CUDC 101 A potent inhibitor of HDACs and receptor tyrosine kinases | 5MG | ₹19095.3 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | EPS003 | CUDC 101 A potent inhibitor of HDACs and receptor tyrosine kinases | 25MG | ₹71445 | 2022-06-14 | Buy |
Properties
Melting point :174-177℃
Density :1.28
storage temp. :-20°C
solubility :DMSO: soluble
form :solid
pka :9.47±0.20(Predicted)
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :PLIVFNIUGLLCEK-UHFFFAOYSA-N
Density :1.28
storage temp. :-20°C
solubility :DMSO: soluble
form :solid
pka :9.47±0.20(Predicted)
color :White or off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
InChIKey :PLIVFNIUGLLCEK-UHFFFAOYSA-N
Safety Information
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Description
CUDC-101 is a multi-target inhibitor, combining functional groups of potent inhibitors of human epidermal growth factor receptor (HER) kinases and histone deacetylases (HDACs). It potently blocks the receptor tyrosine kinases EGFR (aka HER1) and HER2 (IC50s = 2.4 and 16.4 nM, respectively). CUDC-101 also inhibits the activity of class I and class II HDACs at nanomolar concentrations (e.g., IC50s = 4.5, 12.6, 13.2, and 11.4 nM for HDAC1, 2, 4, and 5, respectively). It has only weak effects on over 60 other kinases when tested at 5 μM. CUDC-101 prevents the growth of a wide range of cancer cell lines in vitro, and slows tumor growth or induces tumor regression through cancer cell apoptosis in xenograft models. In cancer cells that have acquired resistance to single-target EGFR inhibitors, CUDC-101 blocks proliferation and reduces cell migration.Related product price
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