GSK 2334470
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- ₹16672.2 - ₹67099.5
- Product name: GSK 2334470
- CAS: 1227911-45-6
- MF: C25H34N8O
- MW: 462.59
- EINECS:
- MDL Number:MFCD21608525
- Synonyms:GSK 2334470;1S,4R)-3-(6-(3-aMino-1H-indazol-6-yl)-2-(MethylaMino)pyriMidin-4-yl)-N-cyclohexyl-4-MethylcyclohexanecarboxaMide;(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide;3-Piperidinecarboxamide, 1-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-, (3S,6R)-;(3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide GSK 2334470;GSK2334470;GSK 2334470;GSK-2334470;((3S,6R)-1-(6-(3-amino-1H-indazol-6-yl)-2-(methylamino)pyrimidin-4-yl)-6-methylpiperidin-3-yl)(piperidin-1-yl)methanone;1S,4R)-3-(6-(3-AMINO-1H-INDAZOL-6-YL)-2-(METHYLAMINO)PYRIMIDIN-4-YL)-N-CYCLOHEXYL-4-METHYLCYCLOHEXAN
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberSML0217
- Product descriptionGSK2334470 ≥98% (HPLC)
- Packaging5MG
- Price₹16672.2
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberSML0217
- Product descriptionGSK2334470 ≥98% (HPLC)
- Packaging25MG
- Price₹67099.5
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | SML0217 | GSK2334470 ≥98% (HPLC) | 5MG | ₹16672.2 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | SML0217 | GSK2334470 ≥98% (HPLC) | 25MG | ₹67099.5 | 2022-06-14 | Buy |
Properties
Density :1.30±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
pka :12.84±0.40(Predicted)
form :powder
color :white to light brown
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
storage temp. :2-8°C
solubility :DMSO: ≥10mg/mL
pka :12.84±0.40(Predicted)
form :powder
color :white to light brown
Stability :Stable for 1 year as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
Safety Information
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Description
3-Phosphoinositide-dependent protein kinase 1 (PDK1) is a serine-threonine kinase that plays an important role in growth factor signaling by phosphorylating and activating a group of kinases, including protein kinase (PK)B, PKA, and certain isoforms of PKC. GSK2334470 is an inhibitor of PDK1 (IC50 = ~10 nM) that even at 100-fold higher concentrations does not affect the activity of 93 other protein kinases, including that of 13 closely related AGC kinase family members. In HEK293 cells, 30 nM - 1 μM GSK2334470 suppresses T-loop phosphorylation and activation of SGK, S6K1, and RSK, as well as the activation of Akt.Related product price
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