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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >GPCR & G Protein >S1P Receptor Inhibitors >PF 543

PF 543

PF 543 Structure
  • ₹11528.63 - ₹46515.03
  • Product name: PF 543
  • CAS: 1415562-82-1
  • MF: C27H31NO4S
  • MW: 465.6
  • EINECS:
  • MDL Number:MFCD23098794
  • Synonyms:PF 543;PF543;PF-543;PF543/PF-543;(2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)Methyl]phenoxy]Methyl]phenyl]Methyl]-2-pyrrolidineMethanol;2-PyrrolidineMethanol, 1-[[4-[[3-Methyl-5-[(phenylsulfonyl)Methyl]phenoxy]Methyl]phenyl]Methyl]-, (2R)-;CS-745;PF-543(freebase)
Price3 Properties Safety Information Description
3 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0234
  • Product descriptionPF-543 hydrochloride ≥98% (HPLC)
  • Packaging5MG
  • Price₹11528.63
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number567741
  • Product descriptionSphingosine Kinase 1 Inhibitor II, PF-543 - CAS 1415562-82-1 - Calbiochem The Sphingosine Kinase 1 Inhibitor II, PF-543 controls the biological activity of Sphingosine Kinase 1. This small molecule/inhibitor is primarily use
  • Packaging5MG
  • Price₹21980
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberPZ0234
  • Product descriptionPF-543 hydrochloride ≥98% (HPLC)
  • Packaging25MG
  • Price₹46515.03
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) PZ0234 PF-543 hydrochloride ≥98% (HPLC) 5MG ₹11528.63 2022-06-14 Buy
Sigma-Aldrich(India) 567741 Sphingosine Kinase 1 Inhibitor II, PF-543 - CAS 1415562-82-1 - Calbiochem The Sphingosine Kinase 1 Inhibitor II, PF-543 controls the biological activity of Sphingosine Kinase 1. This small molecule/inhibitor is primarily use 5MG ₹21980 2022-06-14 Buy
Sigma-Aldrich(India) PZ0234 PF-543 hydrochloride ≥98% (HPLC) 25MG ₹46515.03 2022-06-14 Buy

Properties

Boiling point :666.0±55.0 °C(Predicted)
Density :1.224±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥23.3 mg/mL in DMSO; insoluble in H2O; ≥51 mg/mL in EtOH with gentle warming and ultrasonic
pka :14.77±0.10(Predicted)
form :powder
color :white to light brown
Water Solubility :H2O: 20mg/mL, clear

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

PF-543 is a potent inhibitor of sphingosine kinase 1 (SK1; IC50 = 2-3.6 nM) that less effectively inhibits SK2 (IC50 = 356 nM). It does not significantly block the activity of other protein and lipid kinases, or bind sphingosine-1-phosphate receptors, when tested at a concentration of 10 μM. PF-543 prevents the phosphorylation of sphingosine in cancer cells and in whole blood (EC50s = 8.4 and 27 nM, respectively). Through its effects on SK1, PF-543 prevents sickling, hemolysis, and inflammation in sickling cell disease transgenic mice. Unlike inhibitors that are selective for SK2, PF-543 does not impair DNA synthesis in human pulmonary arterial smooth muscle cells.

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Suppliers and manufacturers

career henan chemical co
PF 543
₹2.00 /1kg
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