PF 543
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- ₹11528.63 - ₹46515.03
- Product name: PF 543
- CAS: 1415562-82-1
- MF: C27H31NO4S
- MW: 465.6
- EINECS:
- MDL Number:MFCD23098794
- Synonyms:PF 543;PF543;PF-543;PF543/PF-543;(2R)-1-[[4-[[3-Methyl-5-[(phenylsulfonyl)Methyl]phenoxy]Methyl]phenyl]Methyl]-2-pyrrolidineMethanol;2-PyrrolidineMethanol, 1-[[4-[[3-Methyl-5-[(phenylsulfonyl)Methyl]phenoxy]Methyl]phenyl]Methyl]-, (2R)-;CS-745;PF-543(freebase)
3 prices
Selected condition:
Brand
- Sigma-Aldrich(India)
Package
- 5MG
- 25MG
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0234
- Product descriptionPF-543 hydrochloride ≥98% (HPLC)
- Packaging5MG
- Price₹11528.63
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product number567741
- Product descriptionSphingosine Kinase 1 Inhibitor II, PF-543 - CAS 1415562-82-1 - Calbiochem The Sphingosine Kinase 1 Inhibitor II, PF-543 controls the biological activity of Sphingosine Kinase 1. This small molecule/inhibitor is primarily use
- Packaging5MG
- Price₹21980
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberPZ0234
- Product descriptionPF-543 hydrochloride ≥98% (HPLC)
- Packaging25MG
- Price₹46515.03
- Updated2022-06-14
- Buy
Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|
Sigma-Aldrich(India) | PZ0234 | PF-543 hydrochloride ≥98% (HPLC) | 5MG | ₹11528.63 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | 567741 | Sphingosine Kinase 1 Inhibitor II, PF-543 - CAS 1415562-82-1 - Calbiochem The Sphingosine Kinase 1 Inhibitor II, PF-543 controls the biological activity of Sphingosine Kinase 1. This small molecule/inhibitor is primarily use | 5MG | ₹21980 | 2022-06-14 | Buy |
Sigma-Aldrich(India) | PZ0234 | PF-543 hydrochloride ≥98% (HPLC) | 25MG | ₹46515.03 | 2022-06-14 | Buy |
Properties
Boiling point :666.0±55.0 °C(Predicted)
Density :1.224±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥23.3 mg/mL in DMSO; insoluble in H2O; ≥51 mg/mL in EtOH with gentle warming and ultrasonic
pka :14.77±0.10(Predicted)
form :powder
color :white to light brown
Density :1.224±0.06 g/cm3(Predicted)
storage temp. :-20°C
solubility :≥23.3 mg/mL in DMSO; insoluble in H2O; ≥51 mg/mL in EtOH with gentle warming and ultrasonic
pka :14.77±0.10(Predicted)
form :powder
color :white to light brown
Safety Information
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Description
PF-543 is a potent inhibitor of sphingosine kinase 1 (SK1; IC50 = 2-3.6 nM) that less effectively inhibits SK2 (IC50 = 356 nM). It does not significantly block the activity of other protein and lipid kinases, or bind sphingosine-1-phosphate receptors, when tested at a concentration of 10 μM. PF-543 prevents the phosphorylation of sphingosine in cancer cells and in whole blood (EC50s = 8.4 and 27 nM, respectively). Through its effects on SK1, PF-543 prevents sickling, hemolysis, and inflammation in sickling cell disease transgenic mice. Unlike inhibitors that are selective for SK2, PF-543 does not impair DNA synthesis in human pulmonary arterial smooth muscle cells.More related product prices
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