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(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one

CAS No.: 76855-69-1

Chemical Name:: (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one

Synonyms: 4-AA;4-ACETOXYAZETIDIN-2-ONE;(3R,4R)-4-ACETOXY-3-[(R)-(T-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE;(3R,4R)-4-ACETOXY-3-[(R)-1-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]AZETIDIN-2-ONE;4-AOSA;Azetidon;4AA(AOSA);AOSA (4-AA);4-AA or 4-AOSA;2-Azacyclobutone

CBNumber:: CB0458274

Molecular Formula:: C13H25NO4Si

Molecular Weight:: 287.43

MOL File:: 76855-69-1.mol

MSDS File:: SDS

Modify Date:: 2023/4/23 13:52:06

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(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Properties

Melting point	107-109 °C(lit.)
alpha	51 º (c=1, chloroform)
Boiling point	358.3±27.0 °C(Predicted)
Density	1.03±0.1 g/cm3(Predicted)
storage temp.	2-8°C
solubility	almost transparency in Methanol
form	powder to crystal
pka	12.86±0.60(Predicted)
color	White to Almost white
optical activity	[α]20/D +51°, c = 1 in chloroform
InChIKey	GWHDKFODLYVMQG-UBHAPETDSA-N
CAS DataBase Reference	76855-69-1(CAS DataBase Reference)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07,GHS09

Signal word

Warning

Hazard statements

H317-H319-H411

Precautionary statements

P273-P280-P302+P352-P305+P351+P338

Hazard Codes

Xi,N

Risk Statements

36-43-51/53

Safety Statements

24-26-37-61

RIDADR

UN 3077 9/PG 3

WGK Germany

HazardClass

PackingGroup

III

HS Code

29337900

NFPA 704

	1
2		0

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one price More Price(3)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich(India)	375845	[3R(1′R,4R)]-(+)-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone 98%	76855-69-1	1G	₹10175.5	2022-06-14	Buy
TCI Chemicals (India)	A1124	(3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone	76855-69-1	5G	₹10600	2022-05-26	Buy
TCI Chemicals (India)	A1124	(3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone	76855-69-1	25G	₹33000	2022-05-26	Buy

Product number	Packaging	Price	Buy
375845	1G	₹10175.5	Buy
A1124	5G	₹10600	Buy
A1124	25G	₹33000	Buy

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Chemical Properties,Uses,Production

Chemical Properties

white to light yellow crystal powde

Uses

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one is an acetoxyazetidinone derivative used as an intermediate in the preparation of carbapenem antibiotics.

Purification Methods

Purify it by chromatography on silica gel (3 x 14cm) for 50g of ester using 20% EtOAc in n-hexane. The eluate is evaporated, and the residue is recrystallised from hexane (white fluffy crystals). [Leanza et al. Tetrahedron 39 2505 1983.]

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Preparation Products And Raw materials

Raw materials

Ethyl acetoacetate Sodium hypochlorite Acetonitrile (R)-(+)-2,2'-Bis(diphenylphosphino)-1,1'-binaphthyl Ethanol

Acetic anhydride Potassium hydroxide (R)-(+)-1,1'-Bi-2-naphthol tert-Butyldimethylsilyl chloride Triethyl orthoformate

2-Mercaptothiazoline Ruthenium(III) chloride Oxygen Triethylamine Palladium

(FORMYLMETHYLENE)TRIPHENYLPHOSPHORANE Benzamide Hydrochloric acid Hydrogen Dichloromethane

1,5-Cyclooctadiene Methanol tert-Butylamine

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Preparation Products

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Suppliers

Global( 387)Suppliers

Supplier	Tel	Country	ProdList	Advantage	Inquiry
A.J Chemicals	91-9810153283	New Delhi, India	6124	58	Inquiry
CLEARSYNTH LABS LTD.	+91-22-45045900	Hyderabad, India	6351	58	Inquiry
TCI Chemicals (India) Pvt. Ltd.	1800 425 7889	New Delhi, India	6778	58	Inquiry
Clearsynth Labs	91-22-45045900	Maharashtra, India	3889	58	Inquiry
Apan Imex Private Limited	91-79-26850087	Gujarat, India	31	58	Inquiry
Bizten Impex Private Limited.	91-40-23510950	Hyderabad, India	109	58	Inquiry
Reax Chemicals	08048372701Ext 416	Hyderabad, India	4223	58	Inquiry
ChemOrbit International	91-40-23712139	Hyderabad, India	264	58	Inquiry
Aditya Molecules	08048601463	Mumbai, India	95	58	Inquiry
Parth Antibiotics Pvt., Ltd.	91-22-25628300	Maharashtra, India	137	58	Inquiry

Supplier	Advantage
A.J Chemicals	58
CLEARSYNTH LABS LTD.	58
TCI Chemicals (India) Pvt. Ltd.	58
Clearsynth Labs	58
Apan Imex Private Limited	58
Bizten Impex Private Limited.	58
Reax Chemicals	58
ChemOrbit International	58
Aditya Molecules	58
Parth Antibiotics Pvt., Ltd.	58

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one Spectrum

(3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one(76855-69-1)MS (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one(76855-69-1)¹HNMR (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one(76855-69-1)IR1 (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one(76855-69-1)IR2 (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one(76855-69-1)Raman

76855-69-1((3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one)Related Search:

Benzyloxyacetyl chloride N-Methyl-2-pyrrolidone Ethyl formate Ethyl propionate Ethyl acrylate

Ethylparaben 2-Butanone oxime Sodium triacetoxyborohydride Dimethyldimethoxysilane Ethylbenzene

Laurocapram 2-Azetidinone Diltiazem hydrochloride 4-Acetoxystyrene Ethyl acetate

Diethoxydimethylsilane Ethanol T-BUTYLDIMETHYLSILANE

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(3s,4r)-4-acetoxy-3-[(r)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one (3R,4R)-(+)-4-ACETOXY-3-[(R)-(T-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE (3R,4R)-4-ACETOXY-3-[(R)-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE (3R,4R)-4-(ACETYLOXY)-3-[(1R)-1-[[(1,1-DIMETHYLETHYL)DIMETHYLSILYL]OXY]ETHYL]-2-AZETIDINONE [3R(1'R,4R)]-(+)-4-ACETOXY-3-[1-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE (2R,3R)-3-[(R)-1-(TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-4-OXOAZETIDIN-2-YLACETATE 4-AOSA (3R,4R)-4-acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone 2-Azetidinone, 4-(acetyloxy)-3-[(1R)-1-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-, (3R,4R)- acetoxyazetidinone (3S,4R)-4-acetoxy-3-[-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one (R R(R))-4-ACETOXY-3-(1-TBDMS-OXY)- (3R(1'R,4R))-(+)-4-ACETOXY-3-(1-(T-BUTYL DI -METHYLSILYLOXY)ETH)-2-AZETIDINONE,98 [3R(1′R,4R)]-(+)-4-Acetoxy-3-[1-(tert-butyldimeth (3R,4R)-4-ACETOXY-3-[(3R)-TERT-BUTYLDIMETHYLSILYLOXY)ETHYL]-2-AZETIDINONE 4-ACETOXYAZETIDINE-2-ONE( 4-AA, ABA, AOSA) (3S)-4-(4'-Fluorophenyl)-3-eth （3S,4R）-4-Acetoxy-3-[(R)-1-(tert-butyl 4-AA (INTERMEDIATE OF CARTAPENEM) 4-ACETOXYAZETIDIN-2-ONE (4-AA , 4-ABA OR 4-AOSA) 4-ACETOXYAZETIDIN-2-ONE 4-AA(AOSA)(PENEM INTERMEDIATE ) 4-acetoxyazetidin-2-one(4AA) ACETOXYSILYLOXYAZETIDINONE 4-Acetoxysilyloxyazetidinone [3R(1''R)4R]-4-Acetoxy-3-[1-(tert-butyldimethylsilyloxy)-ethyl]-2-azetidinon 4AA(AOSA) (2R,3R)-3-(2-(tert-butyldimethylsilyloxy)ethyl)-4-oxoazetidin-2-yl acetate (2R,3R)-3-((R)-1-(tert-butyldimethylsiloxy)ethyl)-4-oxoazetidin-2-yl acetate 4-AA or 4-AOSA 4-acetoxy-3-[1-(butyldimethylsilyloxy)ethyl]-2-azetidinone [3R(1R),4R]-4-Acetoxy-3-[1-(tert-butyldimethylsiloxy)ethyl]-2-azetidinone Carbapenem intermediate: Acetoxyazetidinone (3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone ACETOXYSILYLOXYAZETIDINONE(AOSA) 3R, 4R)-4-acetoxy-3-[(1R)-1-t-butyldimethylsilyloxyethyl]azetidin-2-one intermediates of Meropenem (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidinone AOSA (4-AA) (3R,4R)-4-Acetoxy-3-[(R)-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone ,98% (3S,4R)-4-Acetoxy-3- (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]-2-azetidinone 3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldiMethylsilyloxy)ethyl]-2-a 3-(1-(ButyldiMethylsilyloxy)ethyl)-4-oxoazetidin-2-yl acetate (3S,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldiMethylsilyoxy)ethyl]azetidin-2-one (1'R,3R,4R)-4-Acetoxy-3-(1'-tert-butyldiMethylsilyloxyethyl)-2-azetidinone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldiMethylsiloxy)ethyl]azetidin-2-one (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldiMethylsilyloxy)ethyl]azetidinone [3R-[3α(R*),4β]]-4-(Acetyloxy)-3-[1-[[(1,1-diMethylethyl)diMethylsilyl]oxy]ethyl]-2-azetidinone (3R,4R)-(+)-4-Acetoxy-3-[1-(R)-(tert-butyldiMethylsilyloxy)ethyl]-2-azetidinone, 98% (2R,3S)-3-[(1R)-1-[(tert-butyldiMethylsilyl)oxy]ethyl]-4-oxoazetidin-2-yl acetate 4-AA ((2R,3R)-3-((R)-1-(tert-Butyldimethylsilyloxy)ethyl)-4-oxoazetidin-2-yl acetate) 4- acetoxy azetidone (3R,4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethyl]azetidin-2-one AOSA (4-AA) (3S 4R)-4-Acetoxy-3-[(R)-1-(tert-butyldimethylsilyloxy)ethy (1'R,3R,4R)-4-Acetoxy-3-(1'-tert-butyidimethylsilyloxyethyl)-2-azetidinone 4-AA ((2R,3R)-3-((R)-1 2-Azacyclobutone 2-[3-[1-[tert-butyl(dimethyl)silyl]oxyethyl]-4-oxo-2-azetidinyl]acetate