Prothiofos
- CAS No.
- 34643-46-4
- Chemical Name:
- Prothiofos
- Synonyms
- PROTHIOPHOS;TOKUTHION;Bideron;toyodan;Tokution;ntn-8629;toyothion;bayntn8629;PROTHIOFOS;Tokuthhion
- CBNumber:
- CB9385630
- Molecular Formula:
- C11H15Cl2O2PS2
- Molecular Weight:
- 345.25
- MOL File:
- 34643-46-4.mol
- Modify Date:
- 2024/5/6 18:26:58
| Melting point | 25°C |
|---|---|
| Boiling point | 126.5 °C |
| Density | 1.3000 |
| vapor pressure | 3.0×10-4 Pa (20 °C) |
| storage temp. | APPROX 4°C |
| Water Solubility | 0.07 mg l-1(20 °C) |
| form | liquid |
| BRN | 1998314 |
| CAS DataBase Reference | 34643-46-4(CAS DataBase Reference) |
| NIST Chemistry Reference | Phosphorodithioic acid, o-(2,4-dichlorophenyl) o-ethyl s-propyl ester(34643-46-4) |
| EPA Substance Registry System | Prothiofos (34643-46-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS06,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H330-H410 |
| Precautionary statements | P260-P264-P270-P273-P301+P312-P304+P340+P310 |
| Hazard Codes | Xn,N |
| Risk Statements | 22-50/53 |
| Safety Statements | 60-61 |
| RIDADR | UN 3082 |
| WGK Germany | 3 |
| RTECS | TD5680000 |
Prothiofos Chemical Properties,Uses,Production
Description
Prothiofos is a colorless liquid. It is nearly insoluble in water (1.7 mg/L at 20 ?C) but readily soluble in most organic solvents. Log Kow = 5.67. It is relatively stable in aqueous media; DT50 values (22 ?C) at pH 4, 7, and 9 are 120, 280, and 12 d, respectively.
Uses
Prothiofos is used to control chewing insects in a range of crops including vegetables, fruit, maize, sugar cane and ornamentals.
Definition
ChEBI: An organic thiophosphate that is the 2,4-dichlorophenyl ester of O-ethyl S-propyl dithiophosphoric acid.
Metabolic pathway
A report by Nihon Tokushu Noyaku Seizo K.K. (1979) (now Nhon Bayer Agrochem K.K.) has summarised the nature of the photolysis products and metabolites formed by prothiofos in plants, insects, chicken, mice, rats, guinea-pigs and rabbits. Major routes for the metabolism of prothiofos include activation via oxidative desulfuration to the oxon and detoxification by dearylation to give 2,4-dichlorophenol which occur in all media. In addition, cleavage of the P-S bond and loss of the propanethiol moiety is an important detoxification mechanism in mammals but not insects and dechlorination by reductive loss of the 2-chlorine substituent in the phenyl ring occurs in soil, plants and photochemically. Stage II metabolism results in the formation of the glucoside of 2,4-dichlorophenol in plants and insects and the glucuronide and sulfate ester in mammals.
Metabolism
The principal metabolic routes are activation by oxidative desulfuraton and detoxification by dearylation and cleavage of the P?S bond in both animals and plants. Prothiofos is strongly adsorbed in soil; the half-life under field conditions is 1–2 months.
Prothiofos Preparation Products And Raw materials
Raw materials
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chevron_rightPreparation Products
| Supplier | Tel | Country | ProdList | Advantage | Inquiry |
|---|---|---|---|---|---|
| CLEARSYNTH LABS LTD. | +91-22-45045900 | Hyderabad, India | 6351 | 58 | Inquiry |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | China | 39916 | 58 | Inquiry |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | China | 49391 | 58 | Inquiry |
| career henan chemical co | +86-0371-86658258 +8613203830695 | China | 29826 | 58 | Inquiry |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | China | 49739 | 58 | Inquiry |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | China | 49999 | 58 | Inquiry |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 | China | 23053 | 58 | Inquiry |
| ShenZhen H&D Pharmaceutical Technology Co., LTD | +86-0755-22677845 +86-13627253706 | China | 3144 | 58 | Inquiry |
| LGC Standards | +44 (0)20 8943 8480 | United Kingdom | 6495 | 0 | Inquiry |
| Shaanxi Didu New Materials Co. Ltd | +86-89586680 +86-13289823923 | China | 9003 | 58 | Inquiry |
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