TIQ-A
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- ₹9677.55 - ₹38320.5
- Product name: TIQ-A
- CAS: 420849-22-5
- MF: C11H7NOS
- MW: 201.24
- EINECS:
- MDL Number:MFCD06407947
- Synonyms:Thieno[2,3-c]isoquinolin-5(4H)-one;TIQ-A,poly ADP ribose polymerase,ADP-ribosyltransferase,TIQA,Inhibitor,PARP,TIQ A,inhibit,tankyrases,ADP-ribosylation,poly-ART;TIQ-A, 10 mM in DMSO
2 prices
Selected condition：
Brand
- Sigma-Aldrich(India)
Package
- 1MG
- 5MG
- ManufacturerSigma-Aldrich(India)
- Product numberT2825
- Product descriptionTIQ-A ≥98% (HPLC), solid
- Packaging1MG
- Price₹9677.55
- Updated2022-06-14
- Buy
- ManufacturerSigma-Aldrich(India)
- Product numberT2825
- Product descriptionTIQ-A ≥98% (HPLC), solid
- Packaging5MG
- Price₹38320.5
- Updated2022-06-14
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Sigma-Aldrich(India) | T2825 | TIQ-A ≥98% (HPLC), solid | 1MG | ₹9677.55 | 2022-06-14 | Buy |
| Sigma-Aldrich(India) | T2825 | TIQ-A ≥98% (HPLC), solid | 5MG | ₹38320.5 | 2022-06-14 | Buy |
Properties
Melting point :256-258°C
Boiling point :282.2±9.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 16 mg/mL, soluble
pka :13.04±0.20(Predicted)
form :solid
color :Light green to green
Boiling point :282.2±9.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 16 mg/mL, soluble
pka :13.04±0.20(Predicted)
form :solid
color :Light green to green
Safety Information
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Description
Poly(ADP-ribose) polymerase 1 (PARP1) is a critical DNA repair enzyme involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis. TIQ-A is a PARP1 inhibitor (IC50 = 450 nM in cultured mouse cortical neurons). It displays neuroprotective effects in cultured mouse cortical neurons injured by oxygen-glucose deprivation (IC50 = 0.15 μM). TIQ-A has been used to inhibit eosinophilic infiltration into airways of OVA-challenged mice and to induce the regression of atherosclerotic plaques in high-fat fed apolipoprotein E(-/-) mice.Related product price
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