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TIQ-A

TIQ-A Structure
  • ₹9677.55 - ₹38320.5
  • Product name: TIQ-A
  • CAS: 420849-22-5
  • MF: C11H7NOS
  • MW: 201.24
  • EINECS:
  • MDL Number:MFCD06407947
  • Synonyms:Thieno[2,3-c]isoquinolin-5(4H)-one;TIQ-A,poly ADP ribose polymerase,ADP-ribosyltransferase,TIQA,Inhibitor,PARP,TIQ A,inhibit,tankyrases,ADP-ribosylation,poly-ART
Price2 Properties Safety Information Description
2 prices
Selected condition：

Brand

  • Sigma-Aldrich(India)

Package

  • 1MG
  • 5MG
  • ManufacturerSigma-Aldrich(India)
  • Product numberT2825
  • Product descriptionTIQ-A ≥98% (HPLC), solid
  • Packaging1MG
  • Price₹9677.55
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT2825
  • Product descriptionTIQ-A ≥98% (HPLC), solid
  • Packaging5MG
  • Price₹38320.5
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Sigma-Aldrich(India) T2825 TIQ-A ≥98% (HPLC), solid 1MG ₹9677.55 2022-06-14 Buy
Sigma-Aldrich(India) T2825 TIQ-A ≥98% (HPLC), solid 5MG ₹38320.5 2022-06-14 Buy

Properties

Melting point :256-258°C
Boiling point :282.2±9.0 °C(Predicted)
Density :1.358±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 16 mg/mL, soluble
pka :13.04±0.20(Predicted)
form :solid
color :Light green to green

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning GHS hazard pictograms P261, P271, P304+P340, P312
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.

Description

Poly(ADP-ribose) polymerase 1 (PARP1) is a critical DNA repair enzyme involved in DNA single-strand break repair via the base excision repair pathway. PARP1 is triggered by DNA damage and its excessive activation has been proposed as a causative factor in many pathological conditions including ischemia and reperfusion injury, asthma-related inflammation, and atherogenesis. TIQ-A is a PARP1 inhibitor (IC50 = 450 nM in cultured mouse cortical neurons). It displays neuroprotective effects in cultured mouse cortical neurons injured by oxygen-glucose deprivation (IC50 = 0.15 μM). TIQ-A has been used to inhibit eosinophilic infiltration into airways of OVA-challenged mice and to induce the regression of atherosclerotic plaques in high-fat fed apolipoprotein E(-/-) mice.

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