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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >TGF-beta / Smad >TGF-beta / Smad inhibitors >SB 431542

SB 431542

SB 431542 Structure
  • ₹7400 - ₹17947.85
  • Product name: SB 431542
  • CAS: 301836-41-9
  • MF: C22H16N4O3
  • MW: 384.39
  • EINECS:
  • MDL Number:MFCD05865244
  • Synonyms:SB-431542/SB431542;SB 431542, >=98%;4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide SB431542;SB 431542 4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]benzamide;4-[4-(3,4-Methylenedioxyphenyl)-5-(2-pyridyl)-1H-imidazol-2-yl]-benzamide hydrate;SB 431542;4-(5-BENZOL[1,3]DIOXOL-5-YL-4-PYRLDIN-2-YL-1H-IMIDAZOL-2-YL)-BENZAMIDE;4-[4-(3,4-METHYLENEDIOXYPHENYL)-5-(2-PYRIDYL)-1H-IMIDAZOL-2-YL]-BENZAMIDE
Price5 Properties Safety Information Description
5 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • 100MG
  • ManufacturerTCI Chemicals (India)
  • Product numberB4003
  • Product descriptionSB 431542
  • Packaging25MG
  • Price₹7400
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number616464
  • Product descriptionInSolution TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem The InSolution TGF-β RI Kinase Inhibitor VI, SB431542 controls the biological activity of TGF-β RI. Primarily used for Phosphorylation & Dephosphoryla
  • Packaging5MG
  • Price₹13100
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number616461
  • Product descriptionTGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem TGF-β RI Kinase Inhibitor VI, SB431542, CAS 301836-41-9, is a cell-permeable inhibitor of SMAD2 phosphorylation. Inhibits the activity of ALK4 and ALK
  • Packaging5MG
  • Price₹16960.01
  • Updated2022-06-14
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB4003
  • Product descriptionSB 431542
  • Packaging100MG
  • Price₹17500
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberS4317
  • Product descriptionSB 431542 hydrate ≥98% (HPLC), powder
  • Packaging5MG
  • Price₹17947.85
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B4003 SB 431542 25MG ₹7400 2022-05-26 Buy
Sigma-Aldrich(India) 616464 InSolution TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem The InSolution TGF-β RI Kinase Inhibitor VI, SB431542 controls the biological activity of TGF-β RI. Primarily used for Phosphorylation & Dephosphoryla 5MG ₹13100 2022-06-14 Buy
Sigma-Aldrich(India) 616461 TGF-β RI Kinase Inhibitor VI, SB431542 - CAS 301836-41-9 - Calbiochem TGF-β RI Kinase Inhibitor VI, SB431542, CAS 301836-41-9, is a cell-permeable inhibitor of SMAD2 phosphorylation. Inhibits the activity of ALK4 and ALK 5MG ₹16960.01 2022-06-14 Buy
TCI Chemicals (India) B4003 SB 431542 100MG ₹17500 2022-05-26 Buy
Sigma-Aldrich(India) S4317 SB 431542 hydrate ≥98% (HPLC), powder 5MG ₹17947.85 2022-06-14 Buy

Properties

Melting point :214 °C(dec.)
Boiling point :662.4±55.0 °C(Predicted)
Density :1.373
Flash point :354.4℃
storage temp. :Sealed in dry,Store in freezer, under -20°C
solubility :DMSO: 10 mg/mL, soluble
form :powder
pka :10.14±0.10(Predicted)
color :Yellow
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
InChIKey :FHYUGAJXYORMHI-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

SB-431542 is a potent and selective inhibitor of the TGF-β1 receptor ALK5 (IC50 = 94 nM). It is a less potent antagonist of ALK4 (IC50 = 140 nM) and ALK7. It does not affect the BMP receptors ALK2, ALK3, ALK6, or a panel of other kinases tested. SB-431542 specifically blocks Smad signaling, reducing gene expression relevant to fibrosis and cancer. Through its effects on ALK/Smad signaling, SB-431542 suppresses renewal in embryonic and induced pluripotent stem cells and promotes their differentiation.

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CLEARSYNTH LABS LTD. A.J Chemicals TCI Chemicals (India) Pvt. Ltd.
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Hangzhou FandaChem Co.,Ltd.
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Dayang Chem (Hangzhou) Co.,Ltd.