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ChemicalBook > Product Catalogue >Biochemical Engineering >Inhibitors >PI3K / Akt / mTOR >GSK-3 inhibitors >4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE

4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE Structure
  • ₹6800 - ₹57545.7
  • Product name: 4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
  • CAS: 327036-89-5
  • MF: C10H10N2O2S
  • MW: 222.26
  • EINECS:
  • MDL Number:MFCD04973552
  • Synonyms:GSK-3InhibitorI,TDZD-8;NP 01139;1,2,4-Thiadiazolidine-3,5-dione,2-Methyl-4-(phenylMethyl)-;TDZD-8/TDZD8;4-Benzyl-2-methyl-[1,2,4]thiadiazolidine-3,5-dione TDZD-8;TDZD-8, >=98%;TDZD-8;TDZD 8;TDZD8;NP 01139;2-Methyl-4-(phenylmethyl)-1,2,4-thiadiazolidine-3,5-dione
Price5 Properties Safety Information Description
5 prices
Selected condition：

Brand

  • TCI Chemicals (India)
  • Sigma-Aldrich(India)

Package

  • 5MG
  • 25MG
  • ManufacturerTCI Chemicals (India)
  • Product numberB4436
  • Product description4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
  • Packaging5MG
  • Price₹6800
  • Updated2022-05-26
  • Buy
  • ManufacturerTCI Chemicals (India)
  • Product numberB4436
  • Product description4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
  • Packaging25MG
  • Price₹14000
  • Updated2022-05-26
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product number361540
  • Product descriptionGSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem The GSK-3β Inhibitor I, also referenced under CAS 327036-89-5, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily
  • Packaging5MG
  • Price₹15469.99
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT8325
  • Product descriptionTDZD-8 ≥98% (HPLC), needles
  • Packaging5MG
  • Price₹15966.88
  • Updated2022-06-14
  • Buy
  • ManufacturerSigma-Aldrich(India)
  • Product numberT8325
  • Product descriptionTDZD-8 ≥98% (HPLC), needles
  • Packaging25MG
  • Price₹57545.7
  • Updated2022-06-14
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
TCI Chemicals (India) B4436 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione 5MG ₹6800 2022-05-26 Buy
TCI Chemicals (India) B4436 4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione 25MG ₹14000 2022-05-26 Buy
Sigma-Aldrich(India) 361540 GSK-3β Inhibitor I - CAS 327036-89-5 - Calbiochem The GSK-3β Inhibitor I, also referenced under CAS 327036-89-5, controls the biological activity of GSK-3β. This small molecule/inhibitor is primarily 5MG ₹15469.99 2022-06-14 Buy
Sigma-Aldrich(India) T8325 TDZD-8 ≥98% (HPLC), needles 5MG ₹15966.88 2022-06-14 Buy
Sigma-Aldrich(India) T8325 TDZD-8 ≥98% (HPLC), needles 25MG ₹57545.7 2022-06-14 Buy

Properties

Melting point :63-64.4 °C
Boiling point :335.5±35.0 °C(Predicted)
Density :1.375±0.06 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: 18 mg/mL
pka :-2.08±0.20(Predicted)
form :needles
color :white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H334 May cause allergy or asthma symptoms or breathing difficulties if inhaled Sensitisation, respiratory Category 1 Danger GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P342+P311 IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.

Description

TDZD-8 is a thiadiazolidine derivative that acts as a non-ATP competitive inhibitor of the serine/threonine kinase glycogen synthase kinase 3β (GSK3β; IC50 = 2 μM), binding to the active site of GSK3β. It does not significantly affect the activities of Cdk-1/cyclin B, CK-II, cAMP-dependent protein kinase, or protein kinase C (IC50s = >100 μM). TDZD-8 has been used to study the role of GSK3β during stem cell differentiation as well as in cell and animal models of Alzheimer’s disease and other neurodegenerative disorders.

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Suppliers and manufacturers

career henan chemical co
4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE
₹2.00 /1kg
4-BENZYL-2-METHYL-1,2,4-THIADIAZOLIDINE-3,5-DIONE CAS:327036-89-5
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